Protein Info for CCNA_01707 in Caulobacter crescentus NA1000

Updated annotation (from data): lacC: subunit of periplasmic glucoside 3-dehydrogenase (EC 1.1.99.13)
Rationale: Important for the utilization of lactose, salicin, and raffinose. Previously proposed to be a component of lactose 3-dehydrogenase (PMCID:PMC2863468)
Original annotation: gluconate 2-dehydrogenase subunit 3-family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 182 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF13618: Gluconate_2-dh3" amino acids 41 to 164 (124 residues), 115.5 bits, see alignment E=1.2e-37

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_01707)

MetaCyc: 100% identical to lactose 3-dehydrogenase accessory subunit (Caulobacter vibrioides)
GLUCOSIDE-3-DEHYDROGENASE-RXN [EC: 1.1.2.11]; 1.1.2.11 [EC: 1.1.2.11]

Predicted SEED Role

"FIG00480828: hypothetical protein"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.13

Use Curated BLAST to search for 1.1.2.11 or 1.1.99.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C8M1 at UniProt or InterPro

Protein Sequence (182 amino acids)

>CCNA_01707 lacC: subunit of periplasmic glucoside 3-dehydrogenase (EC 1.1.99.13) (Caulobacter crescentus NA1000)
MLNRRDALRGLALTVGAAATGWAGTAAATTALSWTPTALTPEQAQILDVVAELIIPATDT
PGARAAGVPQFIDRAIANYCEKWQVDQLVGGFARMDADAKAAHGKLFVALAPEQQVAILN
VYDRETAVSTSGHFFPLLEDFVTVGYFTSEPGATLALKYDPVPGAYNGCVPLAEIGRGWA
TR