Protein Info for CCNA_01679 in Caulobacter crescentus NA1000

Annotation: succinylglutamic semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 TIGR03240: succinylglutamate-semialdehyde dehydrogenase" amino acids 5 to 484 (480 residues), 765.9 bits, see alignment E=8.3e-235 PF00171: Aldedh" amino acids 11 to 459 (449 residues), 353.9 bits, see alignment E=5.7e-110

Best Hits

Swiss-Prot: 100% identical to ASTD2_CAUVC: N-succinylglutamate 5-semialdehyde dehydrogenase 2 (astD2) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K06447, succinylglutamic semialdehyde dehydrogenase [EC: 1.2.1.71] (inferred from 100% identity to ccs:CCNA_01679)

Predicted SEED Role

"Succinylglutamic semialdehyde dehydrogenase (EC 1.2.1.71)" in subsystem Arginine and Ornithine Degradation (EC 1.2.1.71)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.71

Use Curated BLAST to search for 1.2.1.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C761 at UniProt or InterPro

Protein Sequence (485 amino acids)

>CCNA_01679 succinylglutamic semialdehyde dehydrogenase (Caulobacter crescentus NA1000)
MSGGLFIDGKWRAGQGAGLSSTDPATGEDVWSAATATPADVADAVAAARKAFPAWADRPR
EERIAILRRYKDILVERAAPYAEALSRETGKALWETRAELASMAGKVDLSIRAYDERTGV
TENAMPFGRAVLRHRAHGVMAVLGPFNFPGHLPNGHIVPALLAGDTVVFKPSEETPLAGQ
LMVEALEAAGAPAGVVNLVQGGRETGQALIAQDIDGLLFTGSAAAGTYFRRYFADRPDVI
LALELGGNNPLVVWNADDAPEAVAALIVQSAFITTGQRCSCARRLIVPDDASGAAIIEAT
VALAERLVIGAWNAENEPFMGPLISGRAAKAAREVASATPGKTILALDGVAGLGDAFLKP
GIVDVTGLETPDEELFAPLLQVRRVSSFDEALAAANATRYGLSAGLISNESELWDKFLSR
IRAGVVNWNRPTTGAAGSMPFGGLGASGNHRPSAYYAADYCAYPVASFEASMVVDTLKDI
KGLKA