Protein Info for CCNA_01666 in Caulobacter crescentus NA1000

Annotation: osmosensitive K+ channel histidine kinase kdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 892 transmembrane" amino acids 396 to 416 (21 residues), see Phobius details amino acids 427 to 455 (29 residues), see Phobius details amino acids 475 to 495 (21 residues), see Phobius details PF02702: KdpD" amino acids 22 to 231 (210 residues), 316.9 bits, see alignment E=1.1e-98 PF13493: DUF4118" amino acids 399 to 505 (107 residues), 81.6 bits, see alignment E=6.9e-27 PF00512: HisKA" amino acids 661 to 728 (68 residues), 50 bits, see alignment 4.9e-17 PF02518: HATPase_c" amino acids 773 to 884 (112 residues), 79.9 bits, see alignment E=3.9e-26

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to ccs:CCNA_01666)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C8H5 at UniProt or InterPro

Protein Sequence (892 amino acids)

>CCNA_01666 osmosensitive K+ channel histidine kinase kdpD (Caulobacter crescentus NA1000)
MPVDDPKRPDPEALLAAANKARRGRLKVFLGMAPGVGKTYEMLRAARRRKAEGADVLIGV
VETHGRRETESLLRGMDVLPRRPIEHRGRVQMEFDIDAALERKPKILLVDEYAHSNAIGS
RHPKRWQDVEELLAAGIDVWTTLNVQHLESLVDVVQRITGVRQRETVPDSALSRADDIEL
VDITPDELRERMAAGKVYVPETARLAADNFFKVENLTALRELALRRAAQTVDDQLIATMR
EKGVEGPWAAGERILVLVSGDAMAATLVRAGRRLSDMMMDAPWIVTHVERTDRPLARDGD
AARLREAYRLAEQLGGATVALSGGDIVDTVMAYARRHNVTQIVIGKSVESRWRELLERSL
AGALLREARGVAVHVVTEAAPEREPRPPAPLRPDRWRGYAVGALFIAAATLAAWGLDVAF
NRVDLGMIFLTAVLAAGVLHGLRPALAAATVAFLVYNCLFLEPRYSFVVGSPTDFITLVV
FWAVALASGGLAGRVREQALGSQRRAAAVTTLLAASRTFSAASGRDAVAKALAEQVSAAA
GGLAVVLLPQGDEIALAHGSPELAPLDAAQMAAARWAWDKGEVAGFGTGTLPQSRWTFWP
LDGVRARTGVAGLAAGAAPLGADQERLVLALLEQGAVALERSQLAAEAVETETLRRADRF
RSALMNSVSHDLRTPLSTVLGASTTLIDYGDKLAKPVREDLVVSIREEAERLNRYVANLL
DMTRIEGGALRLRTDWIDVRDVLNAAADRVSRRLGGRELARDFPRELSLIQADASLLEQV
VVNVLENAIAYSPPEARIEMAAYEDRANVVISIEDEGRGIPTSELERVFDKFRRMEEPSD
RTQGAGLGLSIAKGFIDALGGRIAAASPIHDGRGTRILISLPKTVTTPHHLL