Protein Info for CCNA_01653 in Caulobacter crescentus NA1000

Annotation: cyclophilin-type peptidylprolyl cis-trans isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00160: Pro_isomerase" amino acids 39 to 227 (189 residues), 126.6 bits, see alignment E=5.5e-41

Best Hits

KEGG orthology group: K01802, peptidylprolyl isomerase [EC: 5.2.1.8] (inferred from 100% identity to ccs:CCNA_01653)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C9Y1 at UniProt or InterPro

Protein Sequence (277 amino acids)

>CCNA_01653 cyclophilin-type peptidylprolyl cis-trans isomerase (Caulobacter crescentus NA1000)
MKLATTAAALALAATTVSFGAASAQAVSDWRTPDPNNVLVVETNKGRIIAELYPEVAPNH
VERVRGLAKSGFYDGLTFFRVISDFMAQTGDPKNTGEGGSDLPDLTAEFNFRRGADMPLG
AGFKVGSNESGWVYALPVTSQPSALAVMTADRKVSTWGNFCPGVVGMARAGDPNSANSQF
YFMRAANAGLDKTYTAFGRVLQGVDVVKAIKTGEPVPDPQDKMLSVKVLADIPADKRPTI
QVMDTRGSAFKALVTKRQGELGSSFTNCDVDVPAQVK