Protein Info for CCNA_01615 in Caulobacter crescentus NA1000

Annotation: cell elongation specific D,D-transpeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 672 signal peptide" amino acids 21 to 21 (1 residues), see Phobius details transmembrane" amino acids 22 to 41 (20 residues), see Phobius details TIGR03423: penicillin-binding protein 2" amino acids 20 to 620 (601 residues), 690.5 bits, see alignment E=1e-211 PF03717: PBP_dimer" amino acids 65 to 241 (177 residues), 146.2 bits, see alignment E=1.5e-46 PF00905: Transpeptidase" amino acids 277 to 616 (340 residues), 215.4 bits, see alignment E=1.1e-67

Best Hits

KEGG orthology group: K05515, penicillin-binding protein 2 (inferred from 100% identity to ccr:CC_1546)

Predicted SEED Role

"Penicillin-binding protein 2 (PBP-2)" in subsystem Peptidoglycan Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C8J0 at UniProt or InterPro

Protein Sequence (672 amino acids)

>CCNA_01615 cell elongation specific D,D-transpeptidase (Caulobacter crescentus NA1000)
MSEPSIFFFEVNERQGVFHRRAFLLGGLTGLGLLTLGGRLAQLQLVEAQRYQKLSAGNQF
NYRLVPPPRGLIMDRNGVSLASNRPNFRLMINKEKGLEAEAVLDDLSKLVPIDGTRRARI
LKELDRAPRKAPVVVMEDLSWEEFSRVNIRAPELPNVTADMGEVRVYPFGGAFAHVIGYV
AKVSDRDLKAAEGDATQDQELLHHPGFRIGKQGVEKAFDKDLRGRAGATKTEVDSVGRVV
RLDPAGDIPPVAGKAIHLTLDADIQNRALEVMGEESGAIVVMDCRNGDLLCMASAPSFDA
NRFVRGLSGPEYKALAEYERKPLLDKSMTGLFPPGSTFKPTVGLAALAAGIDPEVRVNCP
GSWYYGGRVWRCWEKGGHGPQNMHDAIKNSCDVYFYQISLKIGPDAIARAARAVGFGQTF
DIGIPGQKKGIVPDREWKKRAFKRNPANQIWFPGETPSYAIGQGALTVNALQLAVMTARL
ANAKKALVPRLIKSIGDMERPAGSDVPDLPFSPEHLAYVRNGMAAVANDVRGTAYRNSQL
GLGDVQMAGKTGTAQVRSYDKGVSRDSKDVRWRLKDHNLFVAFAPYDDPRYAVSVIIEHG
GLGGATAGAPRAREVMRVALLKDPEIRARIERPAPLPEAVPEADIEGAAPEDPVEAPPPA
PEAPTTPQGGQT