Protein Info for CCNA_01577 in Caulobacter crescentus NA1000

Annotation: 2-keto-4-pentenoate hydratase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01557: FAA_hydrolase
  • amino acids 111 to 265 (155 residues), 27.8 bits, E=9.8e-11

Best Hits

KEGG orthology group: K02554, 2-keto-4-pentenoate hydratase [EC: 4.2.1.80] (inferred from 100% identity to ccs:CCNA_01577)

Predicted SEED Role

"2-keto-4-pentenoate hydratase (EC 4.2.1.80)" (EC 4.2.1.80)

MetaCyc Pathways

• 2-hydroxypenta-2,4-dienoate degradation (1/3 steps found)
• catechol degradation I (meta-cleavage pathway) (1/5 steps found)
• catechol degradation II (meta-cleavage pathway) (2/7 steps found)
• toluene degradation II (aerobic) (via 4-methylcatechol) (1/6 steps found)
• toluene degradation I (aerobic) (via o-cresol) (1/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (1/7 steps found)
• 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (1/8 steps found)
• p-cumate degradation (1/8 steps found)
• meta cleavage pathway of aromatic compounds (2/10 steps found)
• toluene degradation IV (aerobic) (via catechol) (4/13 steps found)
• 4-chloronitrobenzene degradation (1/9 steps found)
• L-tryptophan degradation IX (2/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (2/12 steps found)
• p-cymene degradation (1/11 steps found)
• naphthalene degradation to acetyl-CoA (1/12 steps found)
• mandelate degradation to acetyl-CoA (5/18 steps found)
• superpathway of aerobic toluene degradation (12/30 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (12/35 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (8/42 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Benzoate degradation via hydroxylation
• Biphenyl degradation
• Carbazole degradation
• Ethylbenzene degradation
• Fluorene degradation
• Phenylalanine metabolism
• Styrene degradation
• Toluene and xylene degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.80

Sequence Analysis Tools

See A0A0H3C8F6 at UniProt or InterPro

Protein Sequence (272 amino acids)

>CCNA_01577 2-keto-4-pentenoate hydratase family protein (Caulobacter crescentus NA1000)
MTVSKADSEIFTPTAIAPQFVQARQQGVSVPGYPGGVIPSSMADGYAVQDIAIDLWPDEL
VGWKVGLVPPQHRERLGAERLAGCIFKSKVQQASADAPNTFRAIEGGFCAVEAEFIIRLG
KDAPANKTDWTVEEAADYVGELLVGVEIAGSPLKTINALGPTVVASDFGNNDGQIIGQAI
SNWRDLAWEDMPVETFINGKSVGTATAAAIPGSPIAALAFLLGAVAARGKPLKKGQIVTT
GATTGIHDVVAGDVAHISFGPFGTVDCVAVPA