Protein Info for CCNA_01558 in Caulobacter crescentus NA1000

Annotation: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to KDUI_CAUVN: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (kduI) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K01815, 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC: 5.3.1.17] (inferred from 100% identity to ccr:CC_1491)

Predicted SEED Role

"4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 5.3.1.17)

MetaCyc Pathways

4-deoxy-L-threo-hex-4-enopyranuronate degradation (4/5 steps found)
superpathway of microbial D-galacturonate and D-glucuronate degradation (13/31 steps found)

KEGG Metabolic Maps

Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8H5V5 at UniProt or InterPro

Protein Sequence (279 amino acids)

>CCNA_01558 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (Caulobacter crescentus NA1000)
MFAKTYHATHPDMMFAVSNDDLRDRYLMQGLFQDGQIVLTYNHAERFVVGGVVATSPIKL
PDQTEPASAAGHPFLERRELGVINVGDTTGKITVDGVAYEIVPRDGLYVTMGAKDVTFEG
VDGAARFYLVSLPAHAAFETKKLAFADAIPLERGALETSNERTIYQYIVPTTCKSAQLLL
GMTVLKPGSVWNTMPPHLHDRRSEAYFYFGLGENDRVFHYMGEPDEMRHIVIANEEAVMS
PPWSIHMGSGTANYTFIWAMGGENLDYTDMNVLDICQLK