Protein Info for CCNA_01554 in Caulobacter crescentus NA1000

Annotation: D-mannonate oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 482 PF01232: Mannitol_dh" amino acids 38 to 195 (158 residues), 126.6 bits, see alignment E=1e-40 PF08125: Mannitol_dh_C" amino acids 227 to 463 (237 residues), 204.9 bits, see alignment E=1.4e-64

Best Hits

KEGG orthology group: K00040, fructuronate reductase [EC: 1.1.1.57] (inferred from 100% identity to ccs:CCNA_01554)

Predicted SEED Role

"D-mannonate oxidoreductase (EC 1.1.1.57)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.57)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.57

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C9R1 at UniProt or InterPro

Protein Sequence (482 amino acids)

>CCNA_01554 D-mannonate oxidoreductase (Caulobacter crescentus NA1000)
MTANSATSPALRLNATSYPGVVPGVAIPTYDRDKLQIGVVHFGPGAFHRAHQAHYFDQLL
AHDPRWGVCAVSLKSPGVRDALKPQDGLYTLAQLDAETTFRIVGSILEVLVAPEDPPSVF
ARLAAPTTRLVTLTVTEKGYTLSANGGLDESHPDIVHDLANPREPRSAVGYLVEGLRRRF
AAGLAPYAVVACDNLADNGWRLKAAVVAYAAKLDESLAAWIDREGRFPRTMVDSITPATD
DALRARTLAATGLEDAWPIQREAFAQWVVEDVLPADGPDLASVGVIMTDDVRGFERAKLR
LLNGVHSTLAYVGILRGHETVFEAVSDPTLAALASDMMAKDIIPTLTPPRGLDLQAYADA
ILGRFRNPEIRHLLAQIAWDGSQKLPFRILGTLTETLEAGRSIERLAVPLAAWMRFVALR
AKAGEAIVDPLQDRLLALGLAATGEASADVAAFLALDSVFPASLAGDPRFVSALEKAYAD
LG