Protein Info for CCNA_01417 in Caulobacter crescentus NA1000

Annotation: 5-aminolevulinic acid synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 66% identical to HEM1_RHIRD: 5-aminolevulinate synthase (hemA) from Rhizobium radiobacter

KEGG orthology group: K00643, 5-aminolevulinate synthase [EC: 2.3.1.37] (inferred from 100% identity to ccr:CC_1355)

MetaCyc: 58% identical to 5-aminolevulinate synthase 2 (Cereibacter sphaeroides)
5-aminolevulinate synthase. [EC: 2.3.1.37]

Predicted SEED Role

"5-aminolevulinate synthase (EC 2.3.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 2.3.1.37)

MetaCyc Pathways

superpathway of heme b biosynthesis from glycine (7/8 steps found)
tetrapyrrole biosynthesis II (from glycine) (4/4 steps found)
2-amino-3-hydroxycyclopent-2-enone biosynthesis (2/4 steps found)
superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6H4 at UniProt or InterPro

Protein Sequence (408 amino acids)

>CCNA_01417 5-aminolevulinic acid synthase (Caulobacter crescentus NA1000)
MDYKAAFRSAVEQIREEGRYRVFADLKRQRGQFPRATWTRQDGSEHEVVVWCSNDYLGQG
QNPVVLEAMKAAVDEHGSGSGGTRNISGTNHDHVLLEQELADLHGKEAGLLFTSGYVSNE
ATLSVVQKILPGLIIFSDELNHASMIAGIRNGGGPRKIFKHNDLAHLEQLLAEAPADAPK
LIAFESVYSMDGDIADLAGTVALAKKYGAMTYLDEVHAVGMYGPRGGGVAERDGLMGEID
IIEGTLGKAFGVMGGYITGDAEVIDAIRLMASGFIFTTSLPPALTAGALASVRWLKQHPE
VREIHQERAATLKAMFKAAGLPVMDSVSHIVPVLVGDPVHCKMISDMLLADFGVYVQPIN
YPTVPRGTERLRFTPTPFHTDDMMRKLVAAMEKLWAHCNVARMGGYAA