Protein Info for CCNA_01381 in Caulobacter crescentus NA1000

Annotation: valyl-tRNA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 906 transmembrane" amino acids 499 to 517 (19 residues), see Phobius details TIGR00422: valine--tRNA ligase" amino acids 3 to 885 (883 residues), 1074.3 bits, see alignment E=0 PF00133: tRNA-synt_1" amino acids 15 to 588 (574 residues), 490.5 bits, see alignment E=9.8e-151 PF09334: tRNA-synt_1g" amino acids 40 to 91 (52 residues), 27.1 bits, see alignment 4.5e-10 amino acids 377 to 592 (216 residues), 31.7 bits, see alignment E=1.8e-11 PF08264: Anticodon_1" amino acids 630 to 777 (148 residues), 137.8 bits, see alignment E=6.7e-44 PF10458: Val_tRNA-synt_C" amino acids 838 to 902 (65 residues), 65.1 bits, see alignment 1.5e-21

Best Hits

Swiss-Prot: 100% identical to SYV_CAUVC: Valine--tRNA ligase (valS) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

Predicted SEED Role

"Valyl-tRNA synthetase (EC 6.1.1.9)" (EC 6.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C981 at UniProt or InterPro

Protein Sequence (906 amino acids)

>CCNA_01381 valyl-tRNA synthetase (Caulobacter crescentus NA1000)
MLEKTFDPQSVEPRLYAAWEASGAFKPAEDPNAEPFVIVIPPPNVTGSLHIGHALNNTLQ
DVLTRFHRMRGKAALWLPGTDHAGIATQMVVERQLAAAGNIGRRDMGREAFVDKVWEWKA
ESGGAITNQLRRLGASCDWSRERFTLDEGLSAAVRKVFVQLYKQNLLYRDKRLVNWDPQF
QTAISDLEVEQKEVDGAYWHFAYPLADGVTYQHPIAFDEDGKATEFETRDYIVVATTRPE
TMLGDTGVAVHPDDERYKGLVGKFVTLPIVGRRIPIVADDYADPTKGSGAVKITPAHDFN
DFGVGKRAGLEAINILTVEAKLNDSVPAEYVGMDRFVARKAIVARAEEEGWLKEIEKTKH
MVPHGDRSGVVIEPFLTDQWYVDAKTLAQPALKAVETGETIFEPKHWEKTYFEWLRNIEP
WCVSRQLWWGHRIPAWFGPEGSIFVEESEEAAYAAARAQFGADVQLTQDEDVLDTWFSSA
LWPFSTLGWPEKTSDLERFYPTSTLVTGFDIIFFWVARMMMMGIHFMGEAPFKQVFINAL
VRDEKGAKMSKSKGNVMDPLILIDELGCDAVRFTLTAMSGQARDIKLSKQRIEGYRNFGT
KLWNASRFAQMNECVRVEGFDPSTVQQPINKWIRGETVKTVAEVTKALEAPSFDEAAGAL
YRFVWNVFCDWYLELAKPILNGDDAAAKAETRATAAWALDVILKLLHPVMPFITEELWEK
TAEFGPARETMLISAKWPELPADWIDAEAEAEIGWLVETVGEIRSIRAEMNVPPSAKPGL
TIVGAGPETKARLARHRDLLLTLARLDAVREADAAPAGSAPVVMGEATGALGVAEFIDVA
AEKARLTKDIAGHAGEIEKVNKKLGNPDFLARAKEEVVEENRERLAEAEAAKAKLEAALS
RLASVG