Protein Info for CCNA_01327 in Caulobacter crescentus NA1000

Annotation: adenylate kinase/nucleoside-diphosphate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13671: AAA_33
  • amino acids 4 to 139 (136 residues), 35.5 bits, E=1.8e-12
• PF00406: ADK
  • amino acids 5 to 163 (159 residues), 174.5 bits, E=2.5e-55
• PF13207: AAA_17
  • amino acids 6 to 140 (135 residues), 96.1 bits, E=3.4e-31

Best Hits

Swiss-Prot: 100% identical to KAD_CAUVN: Adenylate kinase (adk) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K00939, adenylate kinase [EC: 2.7.4.3] (inferred from 100% identity to ccs:CCNA_01327)

Predicted SEED Role

"Adenylate kinase (EC 2.7.4.3)" in subsystem Purine conversions (EC 2.7.4.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
• superpathway of purine nucleotide salvage (10/14 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.3

Sequence Analysis Tools

See B8H4F5 at UniProt or InterPro

Protein Sequence (191 amino acids)

>CCNA_01327 adenylate kinase/nucleoside-diphosphate kinase (Caulobacter crescentus NA1000)
MNLILFGPPAAGKGTQAKRLVTERGMVQLSTGDMLRAAIASGSELGQRVKGVLDRGELVT
DEIVIALIEDRLPEAEAAGGAIFDGFPRTVAQAEALDKMLAARGQKIDVVLRLKVDEPAL
IERIKKRFEEQGRPDDNPEVFVTRLAAYNAQTAPLLPYYEGQGKLTELDGMGTVEAVAAS
IDSALEPVAAG