Protein Info for CCNA_01239 in Caulobacter crescentus NA1000

Annotation: two-component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 475 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 199 to 218 (20 residues), see Phobius details PF00672: HAMP" amino acids 216 to 268 (53 residues), 30.6 bits, see alignment 3.6e-11 PF02518: HATPase_c" amino acids 368 to 474 (107 residues), 91.4 bits, see alignment E=5.1e-30

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_01239)

Predicted SEED Role

"FIG00481591: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C621 at UniProt or InterPro

Protein Sequence (475 amino acids)

>CCNA_01239 two-component sensor histidine kinase (Caulobacter crescentus NA1000)
MILSRRGAPLFVQALELVIVTLVAAQLISIAVIFTLPPPPPEFYRSSEIVRALKTGQPVQ
PRDGRLLVVKQDGSIRAGNPETPRRADFKAGIGKALGVPANRVELQIDNGPRFFVRRTPV
TPPRPDAPPAGANGRPGAREPFAREGGAPGGGDNARSAQARDEPLIFGDFKVGVRQSDGR
WLVVEPKPTLRFDSWQQRILLILLLSVIAVTPLAWLFARRLAQPITAFADAAERLGKDPR
TPPLNMTGSGEVVAAASAFNMMQERLRRYVEDRTAMVGAIAHDLRTPLTRLKFRIEAAPE
DIRPKLAADIDQMEAMISATLGFVRDTNRPAERTKLELSSLLESVMDEAAETGGDATVER
SEKTVIEGDPVALKRLVSNLVENALKYGGRARGRVFSEDGMAIIEIDDDGPGVPPAELER
VFEPFYRGEPSRNRETGGIGLGLAVVRSLARAHGGDVVLANRLGGGLRATVKLPA