Protein Info for CCNA_01174 in Caulobacter crescentus NA1000

Annotation: LysR-family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 318 PF00126: HTH_1" amino acids 13 to 72 (60 residues), 74.6 bits, see alignment E=4.8e-25 PF03466: LysR_substrate" amino acids 98 to 302 (205 residues), 142.6 bits, see alignment E=1.2e-45

Best Hits

KEGG orthology group: K03566, LysR family transcriptional regulator, glycine cleavage system transcriptional activator (inferred from 100% identity to ccs:CCNA_01174)

Predicted SEED Role

"Glycine cleavage system transcriptional activator GcvA" in subsystem Glycine cleavage system or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C7A7 at UniProt or InterPro

Protein Sequence (318 amino acids)

>CCNA_01174 LysR-family transcriptional regulator (Caulobacter crescentus NA1000)
MERPNERRRLPPLNALRAFEAAARHLNFSRAADELSVTPGAVSQQIQNLEDYVGAALFKR
TPKGLLLTDAAQTALPALREAFDRLAEAASLLTAAVDGRRLTLTAAPSFAAKWLVPRLGK
FEQAHPQVDVWLSAGMEVVDFATGEVDMAIRYGSGRYPGLEVIRLLHETVVPVASPELLE
QNALERPEDLQHHILLHDGSPDADDSCPDWAMWLAARGIRGVDGARGPRFNQSSLVIEAA
ANGRGIALAKRTLAQADLDSGRLVIPFEASTAVDFAYYVVHPKAKGRLPQVKAFVNWLKA
EAEAHEAALRTLDNGAGI