Protein Info for CCNA_01067 in Caulobacter crescentus NA1000

Annotation: type I secretion outer membrane protein RsaFa

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details TIGR01844: type I secretion outer membrane protein, TolC family" amino acids 31 to 435 (405 residues), 237.9 bits, see alignment E=1.1e-74 PF02321: OEP" amino acids 35 to 219 (185 residues), 73 bits, see alignment E=1.4e-24 amino acids 241 to 414 (174 residues), 79.2 bits, see alignment E=1.9e-26

Best Hits

KEGG orthology group: K12535, outer membrane protein RsaF (inferred from 100% identity to ccr:CC_1015)

Predicted SEED Role

"Type I secretion outer membrane protein, TolC precursor" in subsystem Multidrug Resistance Efflux Pumps or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C731 at UniProt or InterPro

Protein Sequence (527 amino acids)

>CCNA_01067 type I secretion outer membrane protein RsaFa (Caulobacter crescentus NA1000)
MRVLSKVLSVRTSLIALAMAMAVVGRADLAHAETLAEAITAAYQSNPNIQAQRAAMRALD
ENYTQARSAYGLQASASVAEVYGWSKGVNAKNGVEAASQTSTLSLSQSLYTNGRFSARLA
GVEAQIKAARENLRRIEMDLLVRVTNAYISVRRDREILRISQGGEAWLQKQLKDTEDKYS
VRQVTLTDVQQAKARLASASTQVANAQAQLNVSVAFYASLVGRQPETLEPEPDIDGLPTT
LDEAFNQAEQANPVLLAAGYTEKASRAGVAEARAQRLFSVGARADYRNGSSTPYYARGGL
REDTVNASITLTQPLFTSGQLNASVRQSIEENNRDKLLMEDARRSMVLSVSQYWDSLVAA
RKSLVSLEEEMKANTIAFYGVREEERFALRSTIEVLNAQAELQNAQINFVRGRANEYVGR
LHLLAQVGTLEVGNLAPGVQPYDPERNFRKVRYRGALPTELIIGTFDKIALPLEPKKPAP
GDTSPIRPPSSELPARPVSADKVTPPASMNDLPALTDDTPVQTAPRN