Protein Info for CCNA_01035 in Caulobacter crescentus NA1000

Annotation: gamma-glutamyltranspeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 630 transmembrane" amino acids 56 to 75 (20 residues), see Phobius details TIGR00066: gamma-glutamyltransferase" amino acids 100 to 621 (522 residues), 552.7 bits, see alignment E=3.8e-170 PF01019: G_glu_transpept" amino acids 115 to 624 (510 residues), 614 bits, see alignment E=1.2e-188

Best Hits

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 100% identity to ccs:CCNA_01035)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.2.2

Use Curated BLAST to search for 2.3.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C5B7 at UniProt or InterPro

Protein Sequence (630 amino acids)

>CCNA_01035 gamma-glutamyltranspeptidase (Caulobacter crescentus NA1000)
MAPLVRSPRRRPGSRSQGSEASSAAQEQPYDLGPGVRRESRIEDARLLNEGLVKPFRLLA
AAASVFALALSPIVSSEALAQKKQLLEYPSIRSPVVGERGMVVSQNAIATKVGADILRQG
GNAVDAAVATAFALAVTLPRAGNIGGDGFMMVHLAKTNETVFIDYRGTAPKAAKLETFVD
ANGKEMDDVASRGYRAPTVPGTVAGLHLAHQKYGRLPWKQVVEPAYRLAADGVVLTPDEA
FVFSWGKERLSESEAGKKAFYKTGGELYRAGEILKQPELAWSLRQIADKGAEAFYRGEIA
QRFAADMKAHGGLITLEDLASYKAEIRQPLVGSYRGLTVKTSPPASAGGATLLEMLNILE
TFDLKATGLGSAKTLHLQAEAMKMAYADRYKYLGDTDFVKVPLQGFTSKAYGVQRAKLID
PDKARPAKELGAGDPWAFESPNTTHFSVADAEGNAVSNTYTLGADFGSGVMVAGAGFVLN
NQMNNYAHKAAWRAQKAGGTLPPNALQPGKRVLSTMMPTMLFKDGKPWLITGTPGGSTII
DTVLQVIVNVVDFKLNVAEATHQPRIFQDASDTLRVEPNFNPDTVAILKAMGHPITSDET
MGSAQSIMIENGLFLGGADPRRPGAEAIAP