Protein Info for CCNA_01017 in Caulobacter crescentus NA1000

Annotation: acyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 530 PF00501: AMP-binding" amino acids 20 to 385 (366 residues), 293.5 bits, see alignment E=2.1e-91 PF13193: AMP-binding_C" amino acids 436 to 511 (76 residues), 82.5 bits, see alignment E=3.4e-27

Best Hits

KEGG orthology group: K01897, long-chain acyl-CoA synthetase [EC: 6.2.1.3] (inferred from 100% identity to ccr:CC_0966)

Predicted SEED Role

"O-succinylbenzoic acid--CoA ligase (EC 6.2.1.26)" in subsystem Menaquinone and Phylloquinone Biosynthesis (EC 6.2.1.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.26, 6.2.1.3

Use Curated BLAST to search for 6.2.1.26 or 6.2.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6Y6 at UniProt or InterPro

Protein Sequence (530 amino acids)

>CCNA_01017 acyl-CoA synthetase (Caulobacter crescentus NA1000)
MSDAIDFDRMNTLGDVPRYHAEARPDAVAFSFEGRETTFAQLDRHTNQVANALLAAGLST
GDRIAYVGKNSDHYFELLLGAAKAGVVTTPIGWRLAAPEIAYIVGDSEAKLVFVGRELIG
HVDAVAAELTHRPVVIAMEAEGAGDYQTFEGWRDAASDVDPHKPIQISDIAIQLYTSGTT
GRPKGAMLTHHNLLGMRREAAKNPLEWNQWGPSDVSLVAMPVAHIGGTGWGLVGLINGAK
GVVAREFDPTKVLDFIEKDRISKMFMVPAALQIVVRLPRAREVDYSRLTHILYGAAPIPL
DLLRECMEVFGCGFVQQYGMTETTGTVVYLPPEDHDPAGNKRMRAAGLPMPGVELKIIDE
AGKSLPPNTVGEVAVRSSANMAGYWKLDEATAKTMDADGWLRTGDAGYLDEDGYLFIHDR
VKDMIISGGENIYPAEVESAVYGHPHVAEVAVIGVPDDKWGEAVKAVVAPKPGVTPDADD
IIAFARTRIAHFKAPKSVDFIPALPRNASGKILRRELRAPYWEGRERQVN