Protein Info for CCNA_01008 in Caulobacter crescentus NA1000

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 554 TIGR01228: urocanate hydratase" amino acids 9 to 551 (543 residues), 960.5 bits, see alignment E=1.3e-293 PF17391: Urocanase_N" amino acids 13 to 136 (124 residues), 200.7 bits, see alignment E=9.5e-64 PF01175: Urocanase" amino acids 139 to 347 (209 residues), 295.9 bits, see alignment E=2.6e-92 PF17392: Urocanase_C" amino acids 350 to 544 (195 residues), 306.4 bits, see alignment E=1e-95

Best Hits

Swiss-Prot: 100% identical to HUTU_CAUVN: Urocanate hydratase (hutU) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 100% identity to ccr:CC_0957)

MetaCyc: 78% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8H2R9 at UniProt or InterPro

Protein Sequence (554 amino acids)

>CCNA_01008 urocanate hydratase (Caulobacter crescentus NA1000)
MTRRDTTRVIRPATGPERTCKSWLTEAALRMLMNNLHPDVAERPEELVVYGGIGRAARDW
ESYDKIVETLRRLEDDETLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWASWEHFNELD
RKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYGGDLSGRWLLTAGLGGMGGAQ
PLAAVMAGAACLAIECQPSSIEMRLRTGYLDRSTDKVEEALAWIEESCAAKTPISVGLLG
NAAELLPELFKRGVRPDLLTDQTSAHDPVNGYLPAGWSLERWHAMRDQDPPQVAEAAKAS
MAAHVKAMLDFQAAGVPTVDYGNNIRQMALEEGVTNAFDFPGFVPAYIRPLFCRGVGPFR
WAALSGDPEDIAKTDAKVKELIPDNPHLHNWLDMAGQKIRFQGLPARICWVGLGDRHRLG
LAFNEMVAKGELKAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGTEAAAKRVARVLWNDPATGVMRHADAGYDIAL
ACAREKGLDLPGIL