Protein Info for CCNA_00994 in Caulobacter crescentus NA1000

Annotation: oxidoreductase, GMC family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 555 PF00732: GMC_oxred_N" amino acids 8 to 307 (300 residues), 193.4 bits, see alignment E=1.2e-60 PF13450: NAD_binding_8" amino acids 11 to 39 (29 residues), 23.1 bits, see alignment (E = 1.8e-08) PF05199: GMC_oxred_C" amino acids 405 to 538 (134 residues), 133.1 bits, see alignment E=2.6e-42

Best Hits

KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 100% identity to ccs:CCNA_00994)

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6W7 at UniProt or InterPro

Protein Sequence (555 amino acids)

>CCNA_00994 oxidoreductase, GMC family (Caulobacter crescentus NA1000)
MTGIIEADYVIVGAGSAGCVLAARLSENGRYKVVLLEAGGDDRPTKNLSQFASNMMIHIP
VGYSSTLKDPKVNWLFTTEPDPGTGGRSHVWPRGKVLGGSSSINAMLYVRGQAADYDGWR
QLGCEGWAWDDVLPYFRKAQNQERGACDLHATGGPLNVADMRDAHPISEALIEACDQAGI
PRYPDLNGADQEGATWYQVTQKNGARCSSAVAYLHPAMKRPNLRVETNALAGRVLFEGKR
AVGVEFMQNGERRAAMARGEVILAGGAINSPQLLQLSGVGAGGLLREHGIEVVADLPGVG
ENLQDHYIVAARYRLKSGTVSVNEQSKGGRLAAEAMKYLLFRKGLLTLSAAHVAAFCKSR
PDLAGPDIQFHILPATMDLDKLFNEQKMELEGAPGMTIAPCQLRPESRGYIRIKSADPSV
YPAIFANYLADPLDQEVIVAGLKWARKIGQQPAIAQYVESEMNPGLEVQTDEQLLDFARQ
TGSTLYHPVGSCQMGTGPMAVVDAQLRVRGVEGLRVVDASIMPRLISGNTNAPSIMIGEK
GADMILAAARQPVAA