Protein Info for CCNA_00922 in Caulobacter crescentus NA1000

Annotation: ClpB protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 859 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 7 to 853 (847 residues), 1421.3 bits, see alignment E=0 PF02861: Clp_N" amino acids 17 to 68 (52 residues), 47.3 bits, see alignment 1.1e-15 amino acids 94 to 144 (51 residues), 42 bits, see alignment 5e-14 PF00004: AAA" amino acids 203 to 316 (114 residues), 42.1 bits, see alignment E=7.2e-14 amino acids 600 to 717 (118 residues), 30.1 bits, see alignment E=3.6e-10 PF17871: AAA_lid_9" amino acids 342 to 444 (103 residues), 125.2 bits, see alignment E=5.8e-40 PF07724: AAA_2" amino acids 594 to 758 (165 residues), 236.6 bits, see alignment E=9.4e-74 PF07728: AAA_5" amino acids 599 to 718 (120 residues), 50.8 bits, see alignment E=1.1e-16 PF10431: ClpB_D2-small" amino acids 764 to 844 (81 residues), 95.9 bits, see alignment E=7.3e-31

Best Hits

Swiss-Prot: 100% identical to CLPB_CAUVC: Chaperone protein ClpB (clpB) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 80% identity to bsb:Bresu_0276)

MetaCyc: 57% identical to protein disaggregase ClpB (Escherichia coli K-12 substr. MG1655)
RXN185E-10

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C855 at UniProt or InterPro

Protein Sequence (859 amino acids)

>CCNA_00922 ClpB protein (Caulobacter crescentus NA1000)
MNIDLYSDRAKQAVQSAQSLALARGHQQFAPEHILKVLLEEKDGLSRALIQSAGGRPDQL
DGGVETLLAKTPRVDGAGGQLYMKPDTARVFAEAEKSAKAAGDAFVTTERLLIAIAKEGG
EAAKLFKEAGVSAQSLETAANAMRKGRTADSANAEEGYEALKRYARDLTAAARDGKLDPV
IGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLALRIVNGDVPESLKDKKLLSL
DMGSLIAGAKYRGEFEERLKAVLGEVTAAEGSIILFIDEMHTLVGAGKGDGAMDASNLLK
PALARGELHCVGATTLDEYRKHVEKDAALARRFQPVFVSEPTVEDTVSILRGLKEKYEVH
HGVRISDSAIVAAATLSNRYIADRFLPDKAIDLVDEASSRVRMQIDSKPEELDEIDRRLV
QLKIEREALSKETDAASKQRLENLEVEIDDLQFRSDEMTARWKAEKEKVGGAAQAREALD
RLRADLANAQRAGDFARAGQIQYGEIPALERRLAEAEAGDTQALTPEVVDAEQIAAVVSR
WTGVPVEKMLEGEREKLLKMEDELRGRVVGQDEALEAVSDAVRRARAGLQDPSKPIGSFL
FLGPTGVGKTELTKSLAEFLFADEAAITRMDMSEYMEKHSVSRLIGAPPGYVGYDEGGAL
TEAIRRRPYQVVLFDEIEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTLIIMTSNLGA
EYLASQEDGEDVEAVRPMVMNTVRGHFRPEFLNRIDEIILFKRLSRHNMGDIVRIQLQRV
EKLLADRRMALALDAEALNWLADKGYDPVYGARPLKRVIQKELVDPIAKKLLAGEIEDGG
VIAVGVTDGQLSFGKAVLQ