Protein Info for CCNA_00900 in Caulobacter crescentus NA1000

Annotation: CHASE4-family GGDEF/EAL protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 735 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 266 to 285 (20 residues), see Phobius details PF05228: CHASE4" amino acids 51 to 224 (174 residues), 57.4 bits, see alignment E=2.8e-19 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 303 to 466 (164 residues), 120.3 bits, see alignment E=3.5e-39 PF00990: GGDEF" amino acids 306 to 463 (158 residues), 131.4 bits, see alignment E=4e-42 PF00563: EAL" amino acids 484 to 712 (229 residues), 238.3 bits, see alignment E=1.2e-74

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_00900)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6L0 at UniProt or InterPro

Protein Sequence (735 amino acids)

>CCNA_00900 CHASE4-family GGDEF/EAL protein (Caulobacter crescentus NA1000)
MKGVEARLSAPLAAMALLTVGVLVAVLFMMAGRVDRDALHHEQALVARGMDSKIADIQRA
VSPQVLWDDAVINLDNRFDAGWAEENIGAYLMGQAGFDMIFVVDAQDRPLFSARVGKPTT
AAYYERRAPSFAPLIRKVRALEVRRPRITGPRVDGGLVATPAQASAVESIDGEVYIVTAS
LVQPDFGKALPRQARAPVVVTALRLDAVFLEAFSSRFLLAGIHLHRSDARPDADDAHVPL
RNHAGQVVATLDWTPPHPGQRLLRKAVVPILLVVGGLAVVALLFARRSRRIAEGLVASEA
RAKHMAMHDALTGLPNRVLFEERLRQGVDGLSRRRGAMAVLAIDLDRFKAVNDTHGHAAG
DELIQVIGARLAGLCRASETLARLGGDEFGVVAAEIDPQGAAALAERLVAALAAPVDLSC
GTVFVGGSVGVAVITPDEAFVGAVEAARRADVAMYRAKDEGRGRYCFFEAEMDAALKARR
GLEADLRLALKDGGVWVAYQPQVDAAGKVLGVEALARWTHPEKGAISPGAFVPLAEDCGL
IDELGRLIMRRAFTDSLRWKDLKVAVNVSALQMRQAGFPDLVAQILAETGARAEKIELEI
TEGALLGDDEATHDAISRLREMGFSLALDDFGTGYSSLSYLRRYPIDKIKIDRSFITPLG
GDKEAGAVVAAIVRLAKALKLSVIAEGVETNQQREQLHEIGCVQAQGFLFSAALAADAID
TIVDEGGRMHLAAVA