Protein Info for CCNA_00857 in Caulobacter crescentus NA1000

Updated annotation (from data): D-xylose transporter
Rationale: Specifically important for D-xylose utilization. Also see PMC2168598 and PMC344409. May also be important for lactose utilization, which is not explained.
Original annotation: glucose/fructose transport protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 478 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 62 to 82 (21 residues), see Phobius details amino acids 93 to 112 (20 residues), see Phobius details amino acids 118 to 140 (23 residues), see Phobius details amino acids 152 to 174 (23 residues), see Phobius details amino acids 194 to 213 (20 residues), see Phobius details amino acids 274 to 297 (24 residues), see Phobius details amino acids 315 to 334 (20 residues), see Phobius details amino acids 342 to 365 (24 residues), see Phobius details amino acids 377 to 404 (28 residues), see Phobius details amino acids 416 to 439 (24 residues), see Phobius details amino acids 445 to 465 (21 residues), see Phobius details TIGR00879: MFS transporter, sugar porter (SP) family" amino acids 19 to 475 (457 residues), 353.9 bits, see alignment E=7e-110 PF00083: Sugar_tr" amino acids 29 to 477 (449 residues), 367.7 bits, see alignment E=9.4e-114 PF07690: MFS_1" amino acids 33 to 428 (396 residues), 112.7 bits, see alignment E=1.9e-36

Best Hits

Swiss-Prot: 51% identical to GLCP_SYNY3: Glucose transport protein (gtr) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K08139, MFS transporter, SP family, sugar:H+ symporter (inferred from 100% identity to ccs:CCNA_00857)

Predicted SEED Role

"D-xylose proton-symporter XylE" in subsystem Xylose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6H3 at UniProt or InterPro

Protein Sequence (478 amino acids)

>CCNA_00857 D-xylose transporter (Caulobacter crescentus NA1000)
MASVSNAGPSAGMSADGGKVNMTFVAAIVAVATIGGFMFGYDSGVINGTQEGLESAFNLS
KLGTGLNVGAILIGCAIGAFAAGRLADVWGRRTVMIISALLFVISAIGTGAAESSIVFII
FRLIGGLGVGAASVLCPVYISEVTPANIRGRLSSVQQIMIITGLTGAFVANYALAHTAGS
STAEFWLGLPAWRWMFWMQIIPAGVFFLCLLGIPESPRYLVAKGKDAQAEAILSRLFGAG
QGAKKVEEIRASLSADHKPTFSDLLDPTTKKLRVILWAGLVLAVFQQLVGINIVFYYGSV
LWQSVGFTEDDSLKINILSGTLSILACLLAIGLIDKIGRKPLLLIGSAGMAVTLGVLTWC
FSTATTVNGALTLGDQIGLTALIAANLYVIFFNLSWGPVMWVMLGEMFPNQMRGSALAVC
GFAQWIANFAISVSFPALAAASLPMTYGFYALSAVVSFFLVQKLVHETRGKELEAMQG