Protein Info for CCNA_00846 in Caulobacter crescentus NA1000

Annotation: proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1029 PF14850: Pro_dh-DNA_bdg" amino acids 57 to 170 (114 residues), 147.8 bits, see alignment E=2.5e-47 PF01619: Pro_dh" amino acids 179 to 470 (292 residues), 310.9 bits, see alignment E=1.4e-96 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 505 to 1008 (504 residues), 606.4 bits, see alignment E=1.9e-186 PF00171: Aldedh" amino acids 557 to 1007 (451 residues), 338.6 bits, see alignment E=8e-105

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 100% identity to ccr:CC_0804)

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88)" in subsystem Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.2.1.88, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.88 or 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C5Q1 at UniProt or InterPro

Protein Sequence (1029 amino acids)

>CCNA_00846 proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase (Caulobacter crescentus NA1000)
MTDWDSLDAGKYRDEAAVIADLLAAKPLSSEDRAAVRAEAEALVRGARRSVRKQGVVESF
LQEFSLGTREGLALMCLAEALLRTPDDDTRDKLIAEKIGSADWASHLGGSDSLFVNASTW
GLMLTGKIVEPDETARNDMPGFIKKLAGRLGEPVIRAAVGQAIRIMGEQFVLGRTIEAAI
KRAAAEGDMCSFDMLGEGARTAADAARYEKAYADAIETVGKLSNGAGPEAGHGVSVKLSA
LCPRYEATHEDRVWEELYPRTLRLAKIAARHNLNFTIDAEEADRLALSLKLLDKLCREPE
LGDWTGLGLAVQAYQKRCGEVIARLKALSEETGRRLMVRLVKGAYWDSEIKRAQVAGRPD
YPVFTTKPATDLSYLVNAKALIEAAPHLYAQFATHNAHTLAAVVRMAKNTGVKIEHQRLH
GMGEALYKAADDLYDGITLRAYAPVGGHEDLLPYLVRRLLENGANTSFVHALLDERVPVE
KVVTDPIDTVEAHPDRHAKIPTPINVYGERRVNSAGLDLSVKADRERLSAAVAAQDGVTL
SAGPLVGGKVVAGGAPLPLIAPANDQKTVGVVSEAQSAQIDEAFKLARAAQPAWDRAGGV
ARAQVLRAMGDALEANIERLIALLSREAGKTLSDGIAEVREAVDFCRYYAMLAEDQFGEA
EILKGPVGETNSLRLAGRGVFVCISPWNFPLAIFTGQIAAALAAGNAVLAKPAEQTPLIA
FEAVKLYHAAGLDPRLLALLPGRGETVGAALTSHEDLDGVAFTGGTDTAWRINQTLAARQ
GPIVPFIAETGGLNGMFVDTTAQREQVIDDVIVSAFGSAGQRCSALRLLFLPHDTADHII
EGLKGAMDALVLGDPALAVTDVGPVIDAEAKDALDKHLVRLKSDAKVLHALAAPAGGTFF
APVLAEIPTADFLEREVFGPVLHVVRYKPENLEKVAGALAARRYGLTLGIHSRIESFAAD
VQRLVPAGNAYVNRSMTGAVVGVQPFGGEGLSGTGPKAGGPHALLRFAVERALSVNITAQ
GGDPALLNL