Protein Info for CCNA_00796 in Caulobacter crescentus NA1000

Annotation: oxygen sensory histidine kinase FixL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 transmembrane" amino acids 18 to 37 (20 residues), see Phobius details amino acids 49 to 77 (29 residues), see Phobius details amino acids 89 to 111 (23 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 122 to 245 (124 residues), 111.5 bits, see alignment E=1.4e-36 PF00989: PAS" amino acids 124 to 234 (111 residues), 67.2 bits, see alignment E=3.9e-22 PF13188: PAS_8" amino acids 124 to 174 (51 residues), 30.4 bits, see alignment 8.2e-11 PF08448: PAS_4" amino acids 129 to 238 (110 residues), 29.3 bits, see alignment E=2.5e-10 PF13426: PAS_9" amino acids 133 to 237 (105 residues), 29.2 bits, see alignment E=2.9e-10 PF00512: HisKA" amino acids 261 to 330 (70 residues), 37.4 bits, see alignment E=6.6e-13 PF02518: HATPase_c" amino acids 374 to 483 (110 residues), 91.3 bits, see alignment E=1.7e-29

Best Hits

KEGG orthology group: K14986, two-component system, LuxR family, sensor kinase FixL [EC: 2.7.13.3] (inferred from 100% identity to ccs:CCNA_00796)

Predicted SEED Role

"Two-component oxygen-sensor histidine kinase FixL" in subsystem Orphan regulatory proteins

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C7U2 at UniProt or InterPro

Protein Sequence (495 amino acids)

>CCNA_00796 oxygen sensory histidine kinase FixL (Caulobacter crescentus NA1000)
MKPTRSLSASLFSDPHPAAYLAAFAAVMATAVARLYLPEAFTAPSSFLLFVPAVLISAAL
GGVGPGVFGTTFAWAAVWWVTRDIPFDLVSGLSAAIFLSVGFGMAVGGGWFHAARRRAAA
VNDHLRSILDTVPDAVVVIDRAGIMTSFSPAAQRMFGWSEAEAIGKNVSLLMPEPYQSAH
DGYLDRYARTGEKRIIGAGRVVVGRRKDGSTFPMELAVGETRGPTPSFTGFIRDLTERQE
TETRLQELQNELVHVSRLTAMGEMASTLAHELNQPLSAIANLLTGSRRLMDRGREADQAK
VRDAIDRAAAQALRAGEVIHRMRDFARRGASEREVESLSKLIEEASALALIGEKERQVDV
RLKLDPKADDVFADRVQIQQVLLNLIRNGIDAMQAQEPRKRALLIRTGLTEEGWSEVSVA
DTGPGIAPEVLERLFQPFMTTKPQGMGVGLSISRSIIEAHGGRIWAEANPGGGALFRFTL
PPAESLAGEKETIDD