Protein Info for CCNA_00785 in Caulobacter crescentus NA1000

Annotation: tRNA methyltransferase/FAD-dependent oxidoreductase MnmC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 591 PF05430: Methyltransf_30" amino acids 110 to 231 (122 residues), 139.4 bits, see alignment E=8.5e-45 PF01266: DAO" amino acids 244 to 560 (317 residues), 123.1 bits, see alignment E=2.9e-39 PF13450: NAD_binding_8" amino acids 246 to 276 (31 residues), 22.7 bits, see alignment (E = 1.4e-08)

Best Hits

Swiss-Prot: 100% identical to MNMC_CAUVC: tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC (mnmC) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_00785)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C4L6 at UniProt or InterPro

Protein Sequence (591 amino acids)

>CCNA_00785 tRNA methyltransferase/FAD-dependent oxidoreductase MnmC (Caulobacter crescentus NA1000)
MTPTAPSPLVWRDDGLPQSSLYGDVYFSSVDGLAETRAVFLAGCGLPERFAERRDFVVGE
LGFGSGLNIAALLDLWRREKPPGGRLHIFSIEAHPLSRDEAARILAHWPELGEAAQVLLD
HWPGRARGFHRVDLPGFDAVLDLAVMDVVEALEAWDGLADAWFLDGFSPALNPAMWRDEV
LAAVGARSAPGARAATFTVAGAVRRGLSAAGFEIAKRPGFGRKRERLEAWRPGVRPVAQR
PETLAIIGGGIAGAALARAARAAGLEVTVIDDADAVAASGNPAALVTPALDAGGGPRAAL
YAQALSRAVTLYEAQPDAVLAREVLQLAAGERDPARFATVADQDLFEPGDMRTLEAEDTR
ARLETPTPALAMAGARVIAPAEVTAAWAGPVVRRRVAKAERDGEGWRLLDAAGEIIARAD
RLALAGGAAGADLLAEAPLRPVRGQASWTRGHGAPATAFGGYAIPTREGLLFGATHDRDD
TQTNVRSEDHARNLATLAKGLPALAARLAGSTFEGRAAIRATTPDRLPLADLREDGVIVL
TGLGSRGFCLAPLLAEHLVARLLDVPSPLPRQLSHLLKLTRFDSPVTRSRL