Protein Info for CCNA_00747 in Caulobacter crescentus NA1000

Annotation: cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 34 to 55 (22 residues), see Phobius details amino acids 65 to 89 (25 residues), see Phobius details PF00563: EAL" amino acids 183 to 423 (241 residues), 125.9 bits, see alignment E=9.1e-41

Best Hits

KEGG orthology group: K13593, cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF (inferred from 100% identity to ccs:CCNA_00747)

Predicted SEED Role

"FIG00484448: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C7P6 at UniProt or InterPro

Protein Sequence (452 amino acids)

>CCNA_00747 cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF (Caulobacter crescentus NA1000)
MGRNGAGTLIYSTLQAGTGLIACNDSCGRFMRRLMLALLTGAYLCLALLVSLFLLRTGAT
PSVGVSAFIGTLGLCFAFHGLIAQALMGAALRVDIDTIREAHAILLDQIEKVDARVTDLV
DTVAADAQRRSEELSSEVHQLEDLIQQMNDRLEHQLTHQVAAASARTGARDRAPQASHML
QVVQDALAENRVDLYLQPIVSLPQRRTVFYESFSRLRDETGRVMMPAEYLAVAEPEGLMT
AIDNLLLFRCVQIVRRLAKQDRKVGIFCNISLASLGDESFFPQFLEFMQGNKDLAGAVFF
ELGQAAFERRGPVEARHMARLASLGFSFSLDKVNDLDVDFQDLARADVKFLKVGAQMMLD
QLEEQDGKLVITSLPDLNASDFAALTRRYGIEVIVEKVEAEKQVAEVLDLDIGYGQGHLF
GEPRAIRDAVLAEADPPADFIRAPMRRRAVGW