Protein Info for CCNA_00725 in Caulobacter crescentus NA1000

Annotation: O6-methylguanine-DNA methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 220 PF02870: Methyltransf_1N" amino acids 62 to 126 (65 residues), 26.8 bits, see alignment E=7.7e-10 TIGR00589: methylated-DNA--[protein]-cysteine S-methyltransferase" amino acids 138 to 217 (80 residues), 113.5 bits, see alignment E=1.8e-37 PF01035: DNA_binding_1" amino acids 139 to 219 (81 residues), 117.9 bits, see alignment E=1.4e-38

Best Hits

KEGG orthology group: K00567, methylated-DNA-[protein]-cysteine S-methyltransferase [EC: 2.1.1.63] (inferred from 100% identity to ccr:CC_0689)

Predicted SEED Role

"Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63)" in subsystem DNA repair, bacterial (EC 2.1.1.63)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.63

Use Curated BLAST to search for 2.1.1.63

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C4G3 at UniProt or InterPro

Protein Sequence (220 amino acids)

>CCNA_00725 O6-methylguanine-DNA methyltransferase (Caulobacter crescentus NA1000)
MRGRCGGPFFVKGGPVFPPLIRPSGPPSPARGEGRNYRADSRARLGDHRPMPRPAHLFLD
RAPSPLGDLLIVTDETGLLRAVDFHDFEPRLRRLARLHYGDLVLETGPAPAAIKAAFARY
FAGDLAALVSLAWATNGTPFQQAVWTALTQIPAGQTITYSELARRAGRPLAIRAAGAANG
ANPLSLVAPCHRVIGTDGALTGYAGGIDRKRWLLAHEGAL