Protein Info for CCNA_00656 in Caulobacter crescentus NA1000

Annotation: type I restriction-modification system methylation subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 611 PF12161: HsdM_N" amino acids 6 to 138 (133 residues), 92.4 bits, see alignment E=4.1e-30 PF02384: N6_Mtase" amino acids 150 to 449 (300 residues), 194.9 bits, see alignment E=2.1e-61

Best Hits

KEGG orthology group: K03427, type I restriction enzyme M protein [EC: 2.1.1.72] (inferred from 100% identity to ccs:CCNA_00656)

Predicted SEED Role

"Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72)" in subsystem Restriction-Modification System (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6A9 at UniProt or InterPro

Protein Sequence (611 amino acids)

>CCNA_00656 type I restriction-modification system methylation subunit (Caulobacter crescentus NA1000)
MNHQSLSAFIWSVADLLRGDYKQSDYGKVILPFTVLRRLDCVLEPTKAAVLAEHEKRAAQ
GVDPEPFLRRVSGAGFYNTHKMDLTRVLGDADNVAANLYAYLQAFSPAVRDIFERFEFHA
QIERLAKAGLLYMVAEKFTRIDLHPEAVDNHQMGLVFEELIRKFAELSNETAGEHFTPRE
VIRLMVELIFVEDDAALSEPGVVRTIYDPTAGTGGMLSVAEERLLQQNPGAKLSMYGQEL
NPESYAICKADMLIKGQPVDNIVFGNTLSDDGHHAAKFDYMLSNPPFGVEWKKVEKIVRA
EAEQQGYNGRFGPGLPRVSDGSLLFLLHLLSKMRPAVDGGSRFGIVLNGSPLFTGGAGSG
ESEIRRHLLESDLVEAIVALPTDMFYNTGIATYVWIVSNKKPAARRGKLQLIDASGFWRK
MRKSLGSKRKEMGEDDIAAITRLFGAFVEAELASVFDAEGKPVDKVIVEAGSAPPVAPEG
GKVKLAPLSKILPNSAFGYRTITVERPLVDEAGKPVLGQKGKNKGKPQADSARRDTENVP
LSEDVETYFAREVLPHAPDAWIDADKTKTGYEIPFNRHFYVFEPPRDLAQIDADLRAVTD
QIKAMIAELAA