Protein Info for CCNA_00612 in Caulobacter crescentus NA1000

Annotation: L-asparaginase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01112: Asparaginase_2
  • amino acids 7 to 285 (279 residues), 254.3 bits, E=7.8e-80

Best Hits

KEGG orthology group: K13051, beta-aspartyl-peptidase (threonine type) [EC: 3.4.19.5] (inferred from 100% identity to ccr:CC_0576)

Predicted SEED Role

"L-asparaginase (EC 3.5.1.1)" in subsystem Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis (EC 3.5.1.1)

MetaCyc Pathways

• L-asparagine degradation III (mammalian) (3/3 steps found)
• L-asparagine degradation I (1/1 steps found)
• superpathway of L-aspartate and L-asparagine biosynthesis (2/4 steps found)
• N-(1-deoxy-D-fructos-1-yl)-L-asparagine degradation (2/5 steps found)
• cyanophycin metabolism (2/6 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Cyanoamino acid metabolism
• Nitrogen metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.4.19.5, 3.5.1.1

Use Curated BLAST to search for 3.4.19.5 or 3.5.1.1

Sequence Analysis Tools

See A0A0H3C7D4 at UniProt or InterPro

Protein Sequence (294 amino acids)

>CCNA_00612 L-asparaginase (Caulobacter crescentus NA1000)
MTDVPYVIALHGGAGVIPGRDYGRALDHLRDLAARMSSKLADGLDAIDAVEIAVTEMEDS
GLYVAGRGSAPNAVGVVEMDASIMDGARHRAGAVCAIQGVASPVGAARQVLEATPHVLLA
GEGASQFARARGLPLIGDPANFYRTPVGLTQADIDAEAAALAHGTVGAVALDRRGALAAA
TSTGGVFGKRPGRVGDTPLPGAGVWADGEVAVSCTGVGEYFILGATAYDVAARLRYAGQS
LDQACQGAIARIGELGGDGGLIAVDRRGRVSFQFNSPGLKRAVAGCGRLTQALI