Protein Info for CCNA_00610 in Caulobacter crescentus NA1000

Annotation: alpha-1,2-mannosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 867 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details TIGR01180: putative alpha-1,2-mannosidase" amino acids 48 to 732 (685 residues), 309.4 bits, see alignment E=2.3e-96 PF17678: Glyco_hydro_92N" amino acids 49 to 273 (225 residues), 157.8 bits, see alignment E=4.4e-50 PF07971: Glyco_hydro_92" amino acids 280 to 728 (449 residues), 365.6 bits, see alignment E=4.7e-113

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_00610)

Predicted SEED Role

"Alpha-1,2-mannosidase" in subsystem Mannose Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C5V0 at UniProt or InterPro

Protein Sequence (867 amino acids)

>CCNA_00610 alpha-1,2-mannosidase (Caulobacter crescentus NA1000)
MNPGKGPVLRFRVQLLVVGFALALGAAHQAQAAPGRALYKLPDLRVGLGDDNQGDTIPGP
TRPNGSIHPSPDTLKASNAGYNPAEPISGFAQLHSQGSGGVTTYGTFLLSPQVGEPVFDE
AAHLSPKADETLAADAYSVRLTRYDTKVEITSAHYAAIYRLTYPTTDQAQVVLDVTRKVG
GLVASEQADVQLFPEQGRIVGHVKAKGYWNPALIDIWFVAEFDQNPTAWGVFDKAERRDG
ALSGRTGSDERLGAWLTFKTTPTKPLLVKIAVSFVSAEMAKALLDREIPDWDFERVRRDT
QAAWNDRLGQVRVEGMTESQQRRFYSALYHASTHPRDRSLDQPAARLGRPNWDEHYTLWD
TYRTLFPLISVLRPSLYTANVNSLIHTFDKFGAADTAIIGGQNYHVGQGGDEVDNVLGEA
LLRGAEGVNWRDAWRVARFNAFERRRPRYLESGYFAVGDRSPEPNNQRAKSGSSTLGFAL
NDFYAAQVAAKAGQTDEAKILTERSANWRKIWNPDATSDGFSGFLMPRYADGKFQDIDPK
LGWDGKVHNNVGYYEGTAWIYSYGVLHDLPGLVEAMGGRVRFNERLNHALDAGLIDITNE
PSFATPWLFHAIGRADLSSRWAGEVVKHFTADAYPGDEDAGAMSSNFVFNSLGLFPKLGS
DLYYLHGPRHGRTVIQLENGKTLEILAAKAGASRPYIASASFNGKPLAGPYVSQAQLLGG
GVLSLSMSDQPGQWIYEGAVLTVRADQPSLVDGKTSTGWRAASGQSVTFSLKAPACIAAY
SVSVGPDQADPSHWTLQAYDGRAWVSVDQQSNVVFDHRHATRTFPLAPGRYARLRWVLDG
GSEASVSEVELIAGASCAAPTSGAPLL