Protein Info for CCNA_00571 in Caulobacter crescentus NA1000

Annotation: phosphoenolpyruvate-protein phosphotransferase/phosphocarrier protein HPr/PTS system, glucose-specific IIA subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 878 transmembrane" amino acids 496 to 514 (19 residues), see Phobius details TIGR00830: PTS system, glucose subfamily, IIA component" amino acids 34 to 154 (121 residues), 130 bits, see alignment E=6.7e-42 PF00358: PTS_EIIA_1" amino acids 34 to 156 (123 residues), 145.3 bits, see alignment E=2e-46 PF00381: PTS-HPr" amino acids 197 to 276 (80 residues), 88.3 bits, see alignment E=7.4e-29 TIGR01003: phosphocarrier, HPr family" amino acids 197 to 276 (80 residues), 70.1 bits, see alignment E=1.8e-23 TIGR01417: phosphoenolpyruvate-protein phosphotransferase" amino acids 316 to 865 (550 residues), 466.1 bits, see alignment E=2.3e-143 PF05524: PEP-utilisers_N" amino acids 317 to 432 (116 residues), 76 bits, see alignment E=7.3e-25 PF00391: PEP-utilizers" amino acids 458 to 530 (73 residues), 68.8 bits, see alignment E=6.5e-23 PF02896: PEP-utilizers_C" amino acids 557 to 840 (284 residues), 340.4 bits, see alignment E=2e-105

Best Hits

KEGG orthology group: K11189, phosphocarrier protein (inferred from 100% identity to ccr:CC_0537)

Predicted SEED Role

"PTS system, glucose-specific IIA component / Phosphocarrier protein of PTS system / Phosphoenolpyruvate-protein phosphotransferase of PTS system (EC 2.7.3.9)" in subsystem Fructose and Mannose Inducible PTS or Mannitol Utilization or Fructose utilization (EC 2.7.3.9)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.9

Use Curated BLAST to search for 2.7.3.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C647 at UniProt or InterPro

Protein Sequence (878 amino acids)

>CCNA_00571 phosphoenolpyruvate-protein phosphotransferase/phosphocarrier protein HPr/PTS system, glucose-specific IIA subunit (Caulobacter crescentus NA1000)
MQKWPCQMVLKWNVVRSAGWTLAERGIQMSALVLTAPLQGWVSALEEAPDAVFAERMLGD
GLAIDPLGSTLHAPCDGSVVSVHRARHAVTLRATNGAEILMHVGLETVALNGEGFEVFVE
EGQTVKAGDRLIGLDLDLLAQRARSLITPVVITNGEAFQIVRRDQDRQIGVGQFLMELSP
IAGASRAAASGAADQITRQIIVPLAHGIHARPAARIAQMAKTFASDLTLATGPRRANARS
PVGLMSLAIRHGDTIQLLASGPDAQAAVTALAELIEGGMGEGAPVAAKTSSTKTAPTKTE
PSEPPPPAPLPRDGVLKGVPAAPGLAIGKAVRLSTAEIVVREAGEGVAHEEAALAVALET
VRARIGKAAETGDKARKAILAAHQAFLDDPELYAGAHRLIAEGKSAGFAWRRAVGGYVQA
LQALGDRRMAERVDDLIDLERQVLRALSGEEETGAALAPGSILLADELLPSQLMGADPAA
LAGFATARGGPTSHVAILAAAMGVPALVAVGGALSKVKDGATLILDADAGTLRVAPDAKA
LEAAQTALAQRQQRKAAAKAAAHEPAVTRDGVRIEVFANTGSVADAQAAVANGAEGSGLL
RTEFLFLDRETPPDEDEQARQYQAIAEALDGRPLIIRTLDVGGDKAAPYLPIPAEENPAL
GLRGVRVSLWRPHLLKAQLRAILRVEPRGQCKIMVPMVASLDELRAVRAVLEEAKRELGI
TDRVQLGVMIETPAAAVTADLLAAEADFLSIGTNDLTQYVLAMDRGNPELAAGIDALHPA
VLRMIDQTCQGAARHHRWVGVCGGLASDLDATPILLGLGVAELSTTASIAPDVKARVRAL
SLEACRALAAQALEQTSPQAVRALVQGQTNTPLGGLNP