Protein Info for CCNA_00562 in Caulobacter crescentus NA1000

Annotation: dihydroorotate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 352 TIGR01036: dihydroorotate dehydrogenase (fumarate)" amino acids 8 to 352 (345 residues), 363.6 bits, see alignment E=4.3e-113 PF01180: DHO_dh" amino acids 43 to 337 (295 residues), 239.5 bits, see alignment E=2.3e-75

Best Hits

Swiss-Prot: 54% identical to PYRD_XANP2: Dihydroorotate dehydrogenase (quinone) (pyrD) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

KEGG orthology group: K00226, dihydroorotate dehydrogenase (fumarate) [EC: 1.3.98.1] (inferred from 100% identity to ccs:CCNA_00562)

Predicted SEED Role

"Dihydroorotate dehydrogenase (EC 1.3.3.1)" in subsystem De Novo Pyrimidine Synthesis (EC 1.3.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.1 or 1.3.98.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C744 at UniProt or InterPro

Protein Sequence (352 amino acids)

>CCNA_00562 dihydroorotate dehydrogenase (Caulobacter crescentus NA1000)
MSLHDIAARALHAFDPEDAHGWAIRGLKWGLGPRDAQPDDPILAVKIAGLELPNCVGLAA
GFDKNAEVPDAMLAAGFGFVEAGTVTPLAQAGNPRPRLFRLTEDQAVINRMGFNNGGLEP
FAQRLAARQGRGGVVGANIGANKDATDRIQDYVTGLTRLWGLSDYFTANISSPNTPGLRA
LQTKAALEELLGRLAETRAALKVASGADYPIFLKVAPDLEDGEVEAIVETVVGAGLDAII
VSNTTIARPETLKSRFAGESGGLSGAPLLEASTAVLARFHAAAAGRVALIGAGGVADGAG
AYAKIRAGARAVQLYSALVYGGPGLVTRIKRDLAARLRADGFAAVEDAIGAA