Protein Info for CCNA_00392 in Caulobacter crescentus NA1000

Annotation: dihydroorotase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00857: dihydroorotase, multifunctional complex type
  • amino acids 23 to 424 (402 residues), 306.8 bits, E=1.2e-95
• PF01979: Amidohydro_1
  • amino acids 53 to 419 (367 residues), 65.1 bits, E=7.2e-22

Best Hits

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 100% identity to ccr:CC_0388)

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• UMP biosynthesis I (5/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Sequence Analysis Tools

See A0A0H3C5S1 at UniProt or InterPro

Protein Sequence (444 amino acids)

>CCNA_00392 dihydroorotase (Caulobacter crescentus NA1000)
MTQTFDLIVRGGEVVNHAGRDFTDIGVRGGKIVAIGDLSQASAGEVFDATGLTVLPGVID
SQVHFREPGLEWKEDLESGSRGAALGGVTAVFEMPNTEPTTTDPDALADKLARAKNRMHT
DHAFYVGGTHANATFLGELERLPGCCGIKVFMGASTGSLLVHDDEGVENVLRHVNRRAAF
HSEDEYRLAERRGLARPGDWTSHPEVRDAQAALQSTHRLVRIAKGLGKRIHVLHVTTKEE
IDFLAQNKDVASVEVTPQHLTLVAPEAYERLKGFAQMNPPIREADHVAGIWRGIDTGVAD
VIGSDHAPHTREEKARPYPASPSGMPGVQTLVPIMLTHVVDGKLTLERFVDLTSHGVNRI
FGLADKGRIAEGFDADFTIVDMKARRVITHDWMATRSGWTPFDGFEAKAWPVATIVRGIV
VMRDDEIIAEGKGEPVRFLETLAG