Protein Info for CCNA_00381 in Caulobacter crescentus NA1000

Annotation: A/G-specific adenine DNA glycosylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 349 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR01084: A/G-specific adenine glycosylase" amino acids 7 to 272 (266 residues), 290.5 bits, see alignment E=7.5e-91 PF00730: HhH-GPD" amino acids 45 to 163 (119 residues), 62.5 bits, see alignment E=6.5e-21 PF00633: HHH" amino acids 109 to 136 (28 residues), 27.4 bits, see alignment (E = 3.3e-10) PF14815: NUDIX_4" amino acids 242 to 336 (95 residues), 54.8 bits, see alignment E=1.2e-18

Best Hits

KEGG orthology group: K03575, A/G-specific adenine glycosylase [EC: 3.2.2.-] (inferred from 100% identity to ccs:CCNA_00381)

Predicted SEED Role

"A/G-specific adenine glycosylase (EC 3.2.2.-)" in subsystem DNA repair, bacterial (EC 3.2.2.-)

Isozymes

Compare fitness of predicted isozymes for: 3.2.2.-

Use Curated BLAST to search for 3.2.2.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6P6 at UniProt or InterPro

Protein Sequence (349 amino acids)

>CCNA_00381 A/G-specific adenine DNA glycosylase (Caulobacter crescentus NA1000)
MKDRDALRSALLAWYDAQARDLAWRVGPAERRAGVRSDPYRVWLSEVMLQQTTVPHATPY
FLSFTQRWPTVLDLAAVEDGDLMAAWAGLGYYARARNLLACARAVANDHGGVFPGTEEGL
RALPGVGAYTAAAVAAIAFDRAANVVDGNVERVMSRLFAVEAPMPDSKPELKALAGDLVT
DDRPGDWAQALMDLGATVCKPKGPLCDRCPVSLWCAAYVGGAPETYPRKTKKADRPRRHG
VAYVLTRGDEVALVRRPPKGLLGGMLGLPTSDWRTASYDDAEAVAAAPLAAAWRDLGAVE
HVFTHFSLTLRVFAADGANDGDFVWTPREGLGALPSVFLKAAMAAQRLL