Protein Info for CCNA_00342 in Caulobacter crescentus NA1000

Annotation: 2-oxoglutarate dehydrogenase E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 987 PF16078: 2-oxogl_dehyd_N" amino acids 15 to 54 (40 residues), 63.5 bits, see alignment (E = 2e-21) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 17 to 985 (969 residues), 1118 bits, see alignment E=0 PF00676: E1_dh" amino acids 247 to 563 (317 residues), 167.3 bits, see alignment E=8.3e-53 PF02779: Transket_pyr" amino acids 632 to 825 (194 residues), 170.4 bits, see alignment E=6e-54 PF16870: OxoGdeHyase_C" amino acids 830 to 986 (157 residues), 164.7 bits, see alignment E=2.6e-52

Best Hits

Swiss-Prot: 64% identical to ODO1_OCHA4: 2-oxoglutarate dehydrogenase E1 component (sucA) from Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 74% identity to aex:Astex_0237)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C4B5 at UniProt or InterPro

Protein Sequence (987 amino acids)

>CCNA_00342 2-oxoglutarate dehydrogenase E1 component (Caulobacter crescentus NA1000)
MADDAGIINQVLTETSFLYGANAAFVEDLYAQWAENPGSVEPSWNAFFASLQEQADQVKR
AAQDPAWTPKKVATVRPDWLSALDGQWATVAPAVEAKVSKAIEAKAPAASAEAVRAATLD
SLRAIMMIRAYRMRGHLAANLDPLGLDPPKDASELDPASYGFSEADYDRPIFLDFVLGLE
TATIREILSIVRRTYCGNVGVQYMHISDPAEKAWLQERIEGRDKEITFSKEGKVAILKKL
IEAEGFERFLHKRFPGTKRFGLDGGEAMVPALEQIIKRGGALGVKDIVLGMPHRGRLNVL
AAVMGKPYHVIFHEFQGGSSVPSDVEGSGDVKYHMGASSDREFDDNKVHLSLTANPSHLE
IVNPVVIGKARAKQAFTLREQPDAGRGHVLPLLLHGDAAFAGQGVVAECFTLSGLKGYRT
GGTIHFIVNNQIGFTTSPRYSRSSPYPSDMALMVEAPIFHVNGDDPEAVVFAAKVSTEYR
QKFGKDVVIDMVCYRRFGHNEGDDPTMTSPLMYAKIKGHPSTRELYSNRLIGEGVITQAD
CDSWVSEFEKFLDAEFDAGKIYKPNKADWLDGKWAGLTLPGDEDRRGKTAFPKTRLLELG
RLITAIPERIDAHKTVRRAIENRRDAFEKGEGIDWGAAEHLAFATLLDEGIPVRLSGQDS
VRGTFTQRHSDIIDQKTEEHYTPLNNIRAGQAHYEVIDSALSEEAVLGFEYGFSLAEPNT
LTLWEGQFGDFVNGAQVVIDQFISSGERKWLRMSGLVMLLPHGYEGQGPEHSSARLERFL
QSCAEDNMQVVNCTTPANYFHALRRQMHREFRKPLIVMAPKSLLRHKRAVSNLSDFAEGS
AFHRVMVDGAEAGCDVGGITLKSDDKIKRVIVCSGKVYFDLVDQRAKLGRDDVYLLRLEQ
FYPWPMKSLMNVLSRFKNADLIWCQEEPRNMGGWTFVDPWLELTLDKLDIKAKRAKYVGR
PASASTAAGLMSRHLKELETFLNEAFA