Protein Info for CCNA_00224 in Caulobacter crescentus NA1000

Annotation: TonB-dependent receptor protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 681 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF07715: Plug" amino acids 45 to 121 (77 residues), 27.9 bits, see alignment E=4.2e-10 PF00593: TonB_dep_Rec" amino acids 235 to 628 (394 residues), 78.1 bits, see alignment E=2e-25 PF14905: OMP_b-brl_3" amino acids 302 to 503 (202 residues), 33 bits, see alignment E=5.6e-12

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccr:CC_0224)

Predicted SEED Role

"Outer membrane receptor proteins, mostly Fe transport" in subsystem Hemin transport system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C698 at UniProt or InterPro

Protein Sequence (681 amino acids)

>CCNA_00224 TonB-dependent receptor protein (Caulobacter crescentus NA1000)
MMTKTMLLASAAAILLASAAQAADLTPEQVAAQAEAAQRGVLIFQPDFFAAQRPNTALEM
VQRVPGFSVQDGSGARGFEGAVGNILINGARPASKNDTGSNVLSRTQANRVERIELIRGG
APGVDMQGYSVVVNVILKKGANRQSIVSWNTSQFDGGRDLYGGSYQFTATDGDKSWGVTL
SDGIGSSDSNGPGTNIRRDSTGKIIRDEKYLNDSWGGGRSIRGNYSAPLAGGKIEATARF
GVNDWNQWQTLTSAIAERRSNYVDDEQSGELGLTYTRPLAPNWALETRAIHSFENFESAS
TSDETLNGVKAAQQRFTAEGDSGESIFRAQLRHDWSKAITVETGGEVAYNMLDVKQAYSV
GGAAVPLPSASVKVEELRGEAFSKATWRVNPRLTLEGGLRLETSTIKQSGDAQNEKSFFY
AKPRFLATWTPAANNQLRFRFERQLGQLDFDDFAASSDLEDGNVYGGNVELKPEQRWITE
IGYERRFWGEGIFAITYRHDEIIGVIDRLPLPGNLSAVGNIGDATLDRLSLNIVVPTDKL
GITGGRFTFKNDWNETHVKDPTTGKDRPISGVRPTQANIGFQQDLLKYKTQWGINWLPLL
GQGTYDVDQTSVWRGAQYYEAFAEYKPTPTLAIRAQLNLWDDFSIRRTVFANRGPNRAIA
FVEDRAINPRTFWQLRIRQTF