Protein Info for CCNA_00078 in Caulobacter crescentus NA1000

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF12418: AcylCoA_DH_N
  • amino acids 2 to 32 (31 residues), 37.1 bits, see alignment (E = 6.2e-13)
• PF02771: Acyl-CoA_dh_N
  • amino acids 41 to 158 (118 residues), 51 bits, E=4.5e-17
• PF02770: Acyl-CoA_dh_M
  • amino acids 163 to 273 (111 residues), 47.5 bits, E=4.2e-16
• PF00441: Acyl-CoA_dh_1
  • amino acids 283 to 452 (170 residues), 65.9 bits, E=1.2e-21
• PF12806: Acyl-CoA_dh_C
  • amino acids 468 to 593 (126 residues), 121 bits, E=8.4e-39

Best Hits

Swiss-Prot: 47% identical to DMDC_RUEPO: 3-methylmercaptopropionyl-CoA dehydrogenase (dmdC) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: K00257, [EC: 1.3.99.-] (inferred from 100% identity to ccr:CC_0080)

MetaCyc: 47% identical to 3-(methylsulfanyl)propanoyl-CoA dehydrogenase monomer (Ruegeria pomeroyi DSS-3)
RXN-12572 [EC: 1.3.99.41]

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

• oleate β-oxidation (29/35 steps found)
• fatty acid salvage (6/6 steps found)
• adipate degradation (5/5 steps found)
• 2-methyl-branched fatty acid β-oxidation (11/14 steps found)
• methylthiopropanoate degradation I (cleavage) (1/6 steps found)
• superpathway of dimethylsulfoniopropanoate degradation (1/8 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• Benzoate degradation via CoA ligation
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Brassinosteroid biosynthesis
• Caprolactam degradation
• Fatty acid metabolism
• Geraniol degradation
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7, 1.3.99.-

Use Curated BLAST to search for 1.3.8.7 or 1.3.99.- or 1.3.99.41

Sequence Analysis Tools

See A0A0H3C3Q3 at UniProt or InterPro

Protein Sequence (597 amino acids)

>CCNA_00078 acyl-CoA dehydrogenase (Caulobacter crescentus NA1000)
MTYQPPVRDHAFILRDVLNIDQHGDLPGFSDAPFDVVEQILEAAAQFTGEVLAPLNTVGD
KTGCKLDPVTNTVTTPPGFKDAYKQMCEGGWTAIGSDPAYGGQGLPHVVNLAFSEMSSSA
NMAFSMYPGLAHGAYSAIHVGGSDEQKQTFLPKMVSGEWTGTMNLTEPHCGTDLGLLRTK
AVPQADGSYKITGQKIWISAGEHDMADNIVHLVLARIEGAPAGVKGISLFIVPKFIPNAD
GSVGPRNEGAKCVGLEEKMGIHGNATCVMQYDEAVGYLIGEENSGLKIMFVMMNEARLGV
GMQGVAQGEAAYQAAVAFAKDRLQGRSLTGPKNAEGPADPIIVHPDVRRMLLESKALIEG
GRAFLFWTALHGDLSHVHPDPAVREKSSDYMGLMTPVLKGYLTDKGFQVCSNAVQVHGGS
GFTEHFPVSQFMRDCRIALIYEGTNGVQALDLVGRKLAAKGGRAVMTFFQEIDQFIGEND
SDEALKPFIEALGGVKAQLQDGTMWLMQNGLQNPDNAGAASTDYMHLFGLAGLAYMWALM
AKAANAKIAAGSSDPFFTTKLTTGRYFIERILPDAASHLAKLKTGSATLMALPAEAF