Protein Info for CCNA_00077 in Caulobacter crescentus NA1000

Annotation: acyl-CoA dehydrogenase, long-chain specific

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 391 PF02771: Acyl-CoA_dh_N" amino acids 17 to 126 (110 residues), 106.6 bits, see alignment E=2e-34 PF02770: Acyl-CoA_dh_M" amino acids 130 to 230 (101 residues), 87.9 bits, see alignment E=8.1e-29 PF00441: Acyl-CoA_dh_1" amino acids 243 to 390 (148 residues), 153.8 bits, see alignment E=8.1e-49 PF08028: Acyl-CoA_dh_2" amino acids 264 to 380 (117 residues), 50.8 bits, see alignment E=4.1e-17

Best Hits

Swiss-Prot: 49% identical to ACADL_MOUSE: Long-chain specific acyl-CoA dehydrogenase, mitochondrial (Acadl) from Mus musculus

KEGG orthology group: K00249, acyl-CoA dehydrogenase [EC: 1.3.99.3] (inferred from 100% identity to ccr:CC_0079)

MetaCyc: 48% identical to long-chain-acyl-CoA dehydrogenase monomer (Homo sapiens)
LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.8]; 1.3.8.8 [EC: 1.3.8.8]; RXN-21775 [EC: 1.3.8.8, 1.3.8.7]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7, 1.3.99.3

Use Curated BLAST to search for 1.3.8.7 or 1.3.8.8 or 1.3.99.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C2N9 at UniProt or InterPro

Protein Sequence (391 amino acids)

>CCNA_00077 acyl-CoA dehydrogenase, long-chain specific (Caulobacter crescentus NA1000)
MSVLNVEKPAFMAEEDIAIFEDAVGKFFDEHASEATVATWRKNHCVDRDMWTKAGEAGLL
GLSTPEQYGGAGGDYRHEVVLMEQLGKKGVDGFGASLHNAIVMPYIVHYGTEEQKQRWLP
RMVTGELVSAIAMTEPGAGSDLQGIKTTAKKAGNQYVINGSKTFITNGQTANLICVVAKT
DPAGGARGTSLIFVETDGPDGLLEGFERGRNLDKLGQEAQDTSELFFNDVKVPTENLLGT
DEGQGFFQLMGQLPQERLNIAVQGMATIERALELTIAYVKDRKAFGKAIIDFQNTQFVLA
ECKTEATVAKVFVNHCIGQHLEGKLDAATASMAKYWVSDLENKIVDRCLQLFGGYGFMNE
YPIARMYKDSRIQRIYGGTNEIMKLLIARTL