Protein Info for CA265_RS24180 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: acriflavin resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1064 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 333 to 353 (21 residues), see Phobius details amino acids 360 to 382 (23 residues), see Phobius details amino acids 388 to 410 (23 residues), see Phobius details amino acids 431 to 453 (23 residues), see Phobius details amino acids 462 to 486 (25 residues), see Phobius details amino acids 531 to 553 (23 residues), see Phobius details amino acids 868 to 889 (22 residues), see Phobius details amino acids 895 to 916 (22 residues), see Phobius details amino acids 922 to 946 (25 residues), see Phobius details amino acids 971 to 993 (23 residues), see Phobius details amino acids 1000 to 1026 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1026 (1023 residues), 855.5 bits, see alignment E=5.2e-261 PF03176: MMPL" amino acids 256 to 495 (240 residues), 36.6 bits, see alignment E=2.7e-13

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 82% identity to phe:Phep_3708)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9ZC49 at UniProt or InterPro

Protein Sequence (1064 amino acids)

>CA265_RS24180 acriflavin resistance protein (Pedobacter sp. GW460-11-11-14-LB5)
MKITDISIKRPSLVIVVFTALTLLGLLSYFSLGYELLPKFSNNVVSISTIYPGASPNEVE
NTVTKKIEDAVSSMENIKKINSVSFESLSTVTITLTDAANIDISLNDAQRKVNAILSDLP
EDVKTPSLSKFSLDDLPVITMSASANMDDITFYDLIDKRIAPVISRVSGIAQVNLVGGSE
REIQVSLNADKLQGYNLSVPQVQQLILSSNLDFPTGSVKTQNQDVLIRLSGKYRSMEELR
NLVLTTTKDGAQIRLGDVADVQDSQKETEKLARIDRKASIAIQIIKQSDANAVEVSKGVH
AIIAKLKTEYAANKLDIRIVNDSSIFTLESADAVIHDLILAVILVAFVMLFFLHSLRNAL
IVMVSIPVSLIATFIGISLFGFTLNLMSLLGLSLVVGILVDDAIVVLENIQRHMEMGKNK
VRAASDATREIGFTVVSITFVIVVVFFPIAVSTGLVSNILRQFCIVVIIATLLSLVASFT
IVPLIFSRFGKLERIEGKNLFGRFILWFEKQLKKFTLWITSILTWSLNHKALTLIIVVVM
FFSSCGLLVGGFIGSEFFPKSDKGEFLVQLELPKDASLEQTNFLTQKAEAFLDKQPEITQ
LITTVGQSTGDFGGTQATAYKSEINVKLVERDQREGVSSDIFATKMSRALAKELIGAKVK
TVPISILGIAENAPIQLVVMGSDLDSALKYAEGAQKVLAAIPGATEIKLSVEKGTPEINV
QVDRDKMSAVGLTLQTVGSTMQTAFAGNTDGKYRKGEYEYDINIQYQNFNRQNIDDVRNL
IFVNSDGKQIKLSQFATITEGSGPSQLERLNKSTSVSVKAQSIGRPTGTVVAEFQAKLEE
LQKNGKLKAPIGVSYSWAGDQENQSEGFGTLGIALLASIILVYLIMVALYDSFIYPLVVM
FSLPLAVIGALLALALTNNSIGIFTILGLIMLMGLVAKNAIILVDFTNHLKAEGKETKEA
LVLANHARLRPILMTTIAMVFGMLPIALASGAGAEWKNGLAWVIVGGLTSSLFLTLIVVP
VVYLMFDRMLERLGFNKKGKTIDELMVEPYDHKDVNEYDLDHGH