Protein Info for CA265_RS22740 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: translation initiation factor IF-2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1032 TIGR00487: translation initiation factor IF-2" amino acids 452 to 1031 (580 residues), 790.2 bits, see alignment E=1.4e-241 PF04760: IF2_N" amino acids 456 to 506 (51 residues), 48.8 bits, see alignment 1.2e-16 TIGR00231: small GTP-binding protein domain" amino acids 534 to 658 (125 residues), 99.1 bits, see alignment E=2.3e-32 PF00009: GTP_EFTU" amino acids 534 to 692 (159 residues), 97.9 bits, see alignment E=1.4e-31 PF01926: MMR_HSR1" amino acids 536 to 642 (107 residues), 36.6 bits, see alignment E=1.1e-12 PF11987: IF-2" amino acids 808 to 922 (115 residues), 136.6 bits, see alignment E=9.6e-44 PF03144: GTP_EFTU_D2" amino acids 953 to 1020 (68 residues), 34.9 bits, see alignment 4.3e-12

Best Hits

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 78% identity to phe:Phep_0141)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9ZBD2 at UniProt or InterPro

Protein Sequence (1032 amino acids)

>CA265_RS22740 translation initiation factor IF-2 (Pedobacter sp. GW460-11-11-14-LB5)
MSDDKPIILIKAIKELNIGMGTAVEFLNKKGFSAEKSPMFKLTGDMYNALLKEYQGDKIV
REEAKQIVIGKIRRDEPETEKPVEAPKKNTDFEKNEEILIKNAQSFTPPVEKPKVVETPK
VETPTPAPAAAVEPVKETKAEDKVEETGLPGVKIVGKIDLNDLNSKTRPAKKEETPAAPA
PVVEPPVVKAPEPVKPVEQPKAEEKPVEVKKEEAPAAPAPAAEPPVVKAPEPVKPVEQPK
VEEKPAEAKPVSNEPEVIKARTVKLTGPNIIGKIVLPTTPDRRNGPVASSSDSEAAKRKR
KRKKTPGAPGQPGQHGGQGQQGQNNPAGQGQGQGGAPGQPRQPYQGNRPGGGTPYQGNRP
AGQGGTPYQGNRNNNNNRPGFQNRNATPSGPKEEPTEKEIQDQIKATLARLSGAGKSGKF
AQRAKLRRQKRDDVASNAEEAANELESQSKILKVTEFVTANELASMMDVPVTKIIGTCMS
LGMFVSINQRLDAETLTIVADEFGYEIQFVKPDEDEENVIEEEDNEADLIERAPVVTIMG
HVDHGKTSLLDYIRKANVVAGEAGGITQHIGAYMVTTPTGKKVTFLDTPGHEAFTAMRAR
GAKAADIAIIVIAADDAVMPQTKEAINHAQAAGVPLVFAFTKVDKPGANADKVREQLSVM
NILVEDWGGKYQSQEISSKSGLNVDLLLDKVLLEAELLELKANPNKRATGTVIESALDKG
RGIVTTVLVQAGTLRVGDPILAGSYSGRVKALTNERGAKVDSAGPSQPVQVLGMQGAPTA
GDRFNALESETEARDIANKRMQLQREQGLRTQKHITLDEIGRRLAIGNFKELNIIVKGDV
DGSIEALADSLLKLSTEQIQINIISKGVGQISESDVLLASASDAIIIGFQVRPSTGARKL
AEAEQIDIRLYSIIYDAINEIKSAMEGMLDPEFEEKIVANVEIRETFKITKVGTIAGCMV
LDGKITRNSKIRIVRDGVVVYTGELASLKRFKDDVKEVNKGYECGLNIQNFNNIEVGDIV
EAYEQVEVARKL