Protein Info for CA265_RS22700 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: pantoate--beta-alanine ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 281 TIGR00018: pantoate--beta-alanine ligase" amino acids 1 to 280 (280 residues), 292.7 bits, see alignment E=2.3e-91 PF02569: Pantoate_ligase" amino acids 3 to 279 (277 residues), 317.3 bits, see alignment E=3.6e-99 TIGR00125: cytidyltransferase-like domain" amino acids 25 to 81 (57 residues), 28 bits, see alignment E=1.9e-10

Best Hits

Swiss-Prot: 44% identical to PANC_GEOSL: Pantothenate synthetase (panC) from Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

KEGG orthology group: K01918, pantoate--beta-alanine ligase [EC: 6.3.2.1] (inferred from 69% identity to phe:Phep_0134)

Predicted SEED Role

"Pantoate--beta-alanine ligase (EC 6.3.2.1)" in subsystem Coenzyme A Biosynthesis (EC 6.3.2.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9ZBZ1 at UniProt or InterPro

Protein Sequence (281 amino acids)

>CA265_RS22700 pantoate--beta-alanine ligase (Pedobacter sp. GW460-11-11-14-LB5)
MEIFKTKAALKAFLKPLKASGKKIALVPTMGALHNGHISLIKLAQQNADIIICSIFVNPT
QFTDPKDLEKYPRPIEHDLAMLADAGCNGVFMPNVEEMYPAGADEAWHIDLGNAEFLLEG
EFRKGHYQGVTQIVKKLFDAVEPDVAMFGQKDFQQVLMIKNMLAYFKLPITIITCPIIRE
DDGLAMSSRNIHLSADDRTHSLVLSKSLQFVTDHFNEYSLAELVDKAKAFYQDIDGVELD
YFTIANGNTLEPAKSTDENNLVALVAAKVGSTRLIDNMIIK