Protein Info for CA265_RS22275 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 668 PF17391: Urocanase_N" amino acids 84 to 210 (127 residues), 177.5 bits, see alignment E=1.4e-56 PF01175: Urocanase" amino acids 213 to 430 (218 residues), 257.1 bits, see alignment E=1.9e-80 PF17392: Urocanase_C" amino acids 436 to 640 (205 residues), 293 bits, see alignment E=1.4e-91

Best Hits

Swiss-Prot: 58% identical to HUTU_DICDI: Probable urocanate hydratase (uroc1) from Dictyostelium discoideum

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 77% identity to phe:Phep_1336)

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9ZAI8 at UniProt or InterPro

Protein Sequence (668 amino acids)

>CA265_RS22275 urocanate hydratase (Pedobacter sp. GW460-11-11-14-LB5)
MDFKAQLLAGIPSTLPAKKPRNTELSHAPVRKDVLTADEKKLAVKNALRYFPKAWHQELA
QEFLTELENYGHIYMYRFMPDYAIYARDIAAYPCLTVHAAAIMLMIQNNLDPAIAQHPEE
LITYGGNGSVFQNWAQYLLTMQYLATMTDQQTLNIYSGHPQGLFPSNTAAPRVVVTNGMM
VPNYSSPEDLEKFNALGVTQYGQMTAGSYMYIGPQGIVHGTAITLMNAFRKKGFYGKDTA
GKIFLTAGLGGMSGAQTKAGNIVGCITVCAEVNPKAATKRQQQGWVDELIDNLDELINRV
IVAQKEKETVSLAYIGNIVDVWERFDQENIEVAIGSDQTSLHNPYSGGYYPVGLSFAEAN
EMMAGAPGQFKVYVQDSLKRQAASINKHTGKGTYFFDYGNAFLLECSRAGADVMSPNGID
FKYPSYVEDILGPLCFDYGFGPFRWVCASGNENDLDLTDQMAKEVMEEIKLSAPAEIQQQ
LQDNINWISAAKENKLVVGSKARILYADAEGRAKIALRFNQAIKTGELSAPVILGRDHHD
VSGTDSPFRETSNIYDGSRFTADMAIHNVIGDSFRGATWVSIHNGGGVGWGEVINGGFGM
VLDGTEQAAEKLQNMLFYDVNNGIARRSWARNKEARFAIEREMERTGTLKITLPNLVDDE
VLDGLEID