Protein Info for CA265_RS18520 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: acetylornithine carbamoyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02729: OTCace_N
  • amino acids 5 to 160 (156 residues), 90.5 bits, E=1.2e-29
• PF00185: OTCace
  • amino acids 203 to 318 (116 residues), 77 bits, E=1.8e-25

Best Hits

KEGG orthology group: K13043, N-succinyl-L-ornithine transcarbamylase [EC: 2.1.3.11] (inferred from 86% identity to phe:Phep_4206)

Predicted SEED Role

"Ornithine carbamoyltransferase (EC 2.1.3.3)" in subsystem Arginine Biosynthesis extended or Arginine Deiminase Pathway or Arginine and Ornithine Degradation (EC 2.1.3.3)

MetaCyc Pathways

• L-arginine biosynthesis I (via L-ornithine) (8/9 steps found)
• L-arginine degradation V (arginine deiminase pathway) (4/4 steps found)
• L-citrulline degradation (3/3 steps found)
• L-arginine biosynthesis II (acetyl cycle) (8/10 steps found)
• L-arginine degradation XIII (reductive Stickland reaction) (4/5 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• urea cycle (3/5 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• superpathway of arginine and polyamine biosynthesis (11/17 steps found)
• L-arginine degradation XIV (oxidative Stickland reaction) (2/6 steps found)
• L-arginine biosynthesis IV (archaea) (4/9 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.3.11 or 2.1.3.3

Sequence Analysis Tools

See A0A1X9Z8F5 at UniProt or InterPro

Protein Sequence (324 amino acids)

>CA265_RS18520 acetylornithine carbamoyltransferase (Pedobacter sp. GW460-11-11-14-LB5)
MKLFTSVHDVPSIKQFVNDALALKANPYAHQDLGKNKTLGLVFMNPSLRTRLSTQKAALN
LGMNVMVMNLDKEGWALETQDGVVMNGSTVEHIREAAAVMGQYCDILGLRSFPKLNNREE
DYSEDFFNKFVKYCAVPVVSLESATRHPLQSFADIITIHETWTKKPDGRKPKVVLAWAPH
VKALPQAVPNSFAEWMCKAQAEGMIDFTIAQPEGYELSEDFTPDANIQYNLEEALAGADY
VYVKNWSSYKEYGKVLTYPDGWMMNNEKLKFTNDAKVMHCLPVRRDLELSSEILDGPNSL
VIHEAGNRLWAAQAVIKAMLEELK