Protein Info for CA265_RS16820 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: type I methionyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 5 to 248 (244 residues), 303.7 bits, E=5.2e-95
• PF00557: Peptidase_M24
  • amino acids 13 to 240 (228 residues), 173 bits, E=3.8e-55

Best Hits

Swiss-Prot: 50% identical to MAP1_CLOPE: Methionine aminopeptidase (map) from Clostridium perfringens (strain 13 / Type A)

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 86% identity to phe:Phep_0623)

MetaCyc: 37% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (4/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.18

Use Curated BLAST to search for 3.4.11.18

Sequence Analysis Tools

See A0A1X9Z7M4 at UniProt or InterPro

Protein Sequence (261 amino acids)

>CA265_RS16820 type I methionyl aminopeptidase (Pedobacter sp. GW460-11-11-14-LB5)
MSKIYYKSLEEIELIRESSMLVSKTLAEVAKVIKAGMTTIQLDKLAYEFISDHGAIPAFL
NYNGFPNSLCISPNEQVVHGFPSEYIIKEGDLISVDCGVIKNNYFGDSAYTFSIGEIDAE
KQKLVEVTKRCLELGIEKAVVGMRIGDIGFAVQQYAEANGFGVVRELVGHGVGVKLHEKP
EVPNYGKRGAGPKLEEGMVIAIEPMINAGVAGVKFHNDGWTVTSKDNKPSAHFEHTVAVK
KGKADVLSTFSIIEEVLQQKK