Protein Info for CA265_RS15950 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: glutamate-1-semialdehyde-2,1-aminomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 TIGR00713: glutamate-1-semialdehyde-2,1-aminomutase" amino acids 30 to 450 (421 residues), 560.8 bits, see alignment E=8.2e-173 PF00202: Aminotran_3" amino acids 59 to 427 (369 residues), 248.3 bits, see alignment E=6.1e-78

Best Hits

Swiss-Prot: 52% identical to GSA_SHEPW: Glutamate-1-semialdehyde 2,1-aminomutase (hemL) from Shewanella piezotolerans (strain WP3 / JCM 13877)

KEGG orthology group: K01845, glutamate-1-semialdehyde 2,1-aminomutase [EC: 5.4.3.8] (inferred from 85% identity to phe:Phep_3448)

Predicted SEED Role

"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.3.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z733 at UniProt or InterPro

Protein Sequence (456 amino acids)

>CA265_RS15950 glutamate-1-semialdehyde-2,1-aminomutase (Pedobacter sp. GW460-11-11-14-LB5)
MLDSLKKMFSGNEADIPVNTGSKPDISRVKSAELYEKSKTYFPGGVNSPVRAFKSVYGTP
LFIEKGDGCYIWDADGNQFIDFCGSWGPLILGHNNPKIREKVTEVMQNGMSFGAPTALEN
ELAELIIKNNRFVEKIRFTSSGTEAVMSAIRLARGFTSRDKILKFEGCYHGHSDSLLVKA
GSGLVTFGETSSAGVPKSFAEETIVVPLNDKTAIEQAFAQFKDQIAAVIIEGIPANNGLI
IQDEEYIHFLRKICTDNGSLLIFDEVITGFRVGFEGAAAHYGVTPDIVTYGKIIGGGLPV
GMYGARAEIMAHISPDGGVYQAGTLSGNPVAMAAGIATLTELNKSSFYKDLNTKAQEFVA
SIQRFATARNYKFKVFTIGSIFWFAFTDKDKIQSADDIDAGSMEKFKIMHRELLNRGIYL
GPSGYEVGFVSSAHTKIELEKAKRAIFEALDLVFKK