Protein Info for CA265_RS14290 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: valine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 888 TIGR00422: valine--tRNA ligase" amino acids 4 to 869 (866 residues), 904.7 bits, see alignment E=3e-276 PF00133: tRNA-synt_1" amino acids 15 to 584 (570 residues), 431 bits, see alignment E=1.1e-132 PF09334: tRNA-synt_1g" amino acids 41 to 188 (148 residues), 28.9 bits, see alignment E=1.3e-10 PF13603: tRNA-synt_1_2" amino acids 241 to 300 (60 residues), 33 bits, see alignment 1.1e-11 PF08264: Anticodon_1" amino acids 625 to 767 (143 residues), 107 bits, see alignment E=2e-34 PF10458: Val_tRNA-synt_C" amino acids 823 to 887 (65 residues), 45.4 bits, see alignment 2.1e-15

Best Hits

KEGG orthology group: K01873, valyl-tRNA synthetase [EC: 6.1.1.9] (inferred from 86% identity to phe:Phep_1244)

Predicted SEED Role

"Valyl-tRNA synthetase (EC 6.1.1.9)" (EC 6.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z6Z6 at UniProt or InterPro

Protein Sequence (888 amino acids)

>CA265_RS14290 valine--tRNA ligase (Pedobacter sp. GW460-11-11-14-LB5)
MSISTKYNPAETEDKWYSYWLSKKFFHSEPDEREPYTIVIPPPNVTGVLHMGHMLNNTIQ
DVLIRKARMQGKNACWVPGTDHASIATEAKVVAMLKEQGINKKDLSREEFLKYAWEWKEK
YGGIILEQLKKLGASCDWDRTRFTMEEDLSEAVIDSFIHLYKKGWIYRGIRMVNWDPAGK
TAVSDEEVIRKEVNQKLYYIKYLISGTEDQFLTIATTRPETIMADAAICINPNDERFMHL
KGKKVFVPLVNHEIPVIEDEYVDIEFGTGCLKVTPAHDLNDYELGVKHNLPVTDILNDDG
TLNELAVILVGEDRFVARKKIAKMLEEAGHLEKVEDYKSQVGFSERTDAAIEPKLSMQWF
VKMKEMAQPALDDVLNGEVNLIPNKFENTYRHWMENVRDWNISRQLWWGQRIPAWYDDKG
NWVVAKTKDEALEEFWKKKHLDESCSETEKAGFKHQLEPFLRQDDDVMDTWFSSWLWPIS
VFDGFKNPENKDINYYYPTNDLVTAPEILFFWVARMIMAGHEFMGKKPFTNVYLTGIVRD
KLGRKMSKSLGNSPDPIGLIEKYGADAVRVGMLMSSPAGNDLMFDESYCEQGRNFASKIW
NAFRLVKGWEVDDNLANPNTQAIAWFENRFNEALVEIEANFKQYRLSEALMITYKLVWDD
FCAWYLEMVKPAYQQPIDAESYKATIAFFENIIKLLHPNMPFITEELWHDDLFAGRGEMD
CCIVAEFPKGGTFDEKLLKDAEVIKTVVAEIRNVRNQKQISPKEALPLSIKINSDLDYEK
WLNIVFKLANVSEAEIVNDKIVGATAFMAGKDEFFIPLTENVDIEAERERLNADLIYLQG
FLKSVDAKLSNERFVQNAKPEIIANERNKKADAEAKIKIIEESLAVLG