Protein Info for CA265_RS11965 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: error-prone DNA polymerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1076 TIGR00594: DNA polymerase III, alpha subunit" amino acids 3 to 981 (979 residues), 592.6 bits, see alignment E=8.6e-182 PF02811: PHP" amino acids 6 to 151 (146 residues), 58.2 bits, see alignment E=3.4e-19 PF07733: DNA_pol3_alpha" amino acids 279 to 533 (255 residues), 293.9 bits, see alignment E=3e-91 PF17657: DNA_pol3_finger" amino acids 536 to 702 (167 residues), 197.5 bits, see alignment E=2.5e-62 PF14579: HHH_6" amino acids 776 to 863 (88 residues), 52.5 bits, see alignment E=1.2e-17 PF01336: tRNA_anti-codon" amino acids 946 to 1018 (73 residues), 38 bits, see alignment 3.3e-13

Best Hits

KEGG orthology group: K14162, error-prone DNA polymerase [EC: 2.7.7.7] (inferred from 70% identity to dfe:Dfer_2345)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z5J9 at UniProt or InterPro

Protein Sequence (1076 amino acids)

>CA265_RS11965 error-prone DNA polymerase (Pedobacter sp. GW460-11-11-14-LB5)
MEYTELQVTSNFSFLRGASHPEELVKEAAKMGYKKIAITDHNTLAGIVRAHAQARKHNIE
IIPACRLNLVDGASLLAYPTDTESYGRLSALLSLGNLRTEKGSCQLYKKDVFEYAQGIIF
IAIPPENLSEGFDFQLNFYADLQSYQNALKENLYLAINRTYQGEDQKRMFRLAKLSQKTG
IPLAATNDVYYHSPNRRELQDVLSCVREKCTIHNAGYLLFQNAERHLKPEAEMKRLFRQY
PQALENTVKISQKCTFSLDSLKYIYPEEITSEGRTPQQELQYLTMKGAYELFGDELPKKV
TDNISHEMKFVEEMNYASYFLTVYDIVRFARSQHILCQGRGSAANSTICYCLGITSVDPT
KFDLLFERFISSARNEPPDIDVDFEHERREEVIQYIYQKYGRDRAAIVATVTQQRQKGAI
RDVGKVMGLSVDTINRLSSSIWEFTDEWFEGGKLTEQGLNPNDPLLRKVLSLTAKMMGFP
RQLGQHTGGFVITRGKLTDLCPILNARMEDRTNIEWNKDDIDTLGFLKIDVLALGMLTCI
RKGFDLAKAHYNLELTMGKINEVEDPKVYEMISHADTLGVFQIESRAQMSMLPRLRPKKF
YDLVIEVAIVRPGPIQGDMVHPYLKRRNGEEKVDYPSEELKEILHRTLGVPLFQEQAMKI
AIVAAGFTPAEADELRRSMATFKAKGMVTKFEQKLISGMTSKGYSEDFAKRVFKQLEGFG
SYGFPESHAASFALLVYVSCWLKCYYPDVFATALLNSMPMGFYQPAQIVIDAKKHGVEIR
PIDINYSAWDNLLEEKSGKYHAIRLGFRQIKGMKAEDIELLDKGRKKGYGHIHQLMDAGV
SLSALERLADADAFGSIGLDRRAALWEVSAMADRPVALFENQPSESSLETQATLPLMSKG
EHVIQDYASTSLSLKAHPVSFVREQLSLLHVLPTKSLASAKDGQSVKVAGLVLVRQRPGT
AKGVCFITIEDETGFTNLVVFENLFEKFRKEIIQSRLLMVEGKLQIEGEVIHVIVKRCFD
LTRLLRSIDRADQNDFPAVAFSRSDERTAPYPTGQKDRPEKNTQTTSAIPGGRNFK