Protein Info for CA265_RS10150 in Pedobacter sp. GW460-11-11-14-LB5
Annotation: cysteine synthase B
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 56% identical to CYSM_SALTY: Cysteine synthase B (cysM) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG orthology group: K12339, cysteine synthase B [EC: 2.5.1.47] (inferred from 77% identity to psn:Pedsa_3672)MetaCyc: 55% identical to cysteine synthase B (Escherichia coli K-12 substr. MG1655)
Cystathionine gamma-lyase. [EC: 4.4.1.1, 4.4.1.28]; Cysteine synthase. [EC: 4.4.1.1, 4.4.1.28, 2.5.1.47]; SULFOCYS-RXN [EC: 4.4.1.1, 4.4.1.28, 2.5.1.47, 2.5.1.144]
Predicted SEED Role
"Cysteine synthase (EC 2.5.1.47)" in subsystem Cysteine Biosynthesis or Methionine Biosynthesis (EC 2.5.1.47)
MetaCyc Pathways
- superpathway of branched chain amino acid biosynthesis (17/17 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- L-isoleucine biosynthesis I (from threonine) (7/7 steps found)
- superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (9/10 steps found)
- L-cysteine degradation II (3/3 steps found)
- L-serine degradation (3/3 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- L-threonine degradation I (5/6 steps found)
- superpathway of L-cysteine biosynthesis (fungi) (5/6 steps found)
- L-cysteine biosynthesis I (2/2 steps found)
- L-cysteine biosynthesis III (from L-homocysteine) (2/2 steps found)
- superpathway of L-cysteine biosynthesis (mammalian) (4/5 steps found)
- L-cysteine biosynthesis VII (from S-sulfo-L-cysteine) (3/4 steps found)
- homocysteine and cysteine interconversion (3/4 steps found)
- D-serine degradation (2/3 steps found)
- L-methionine degradation II (2/3 steps found)
- L-tryptophan degradation II (via pyruvate) (2/3 steps found)
- hydrogen sulfide biosynthesis II (mammalian) (4/6 steps found)
- seleno-amino acid biosynthesis (plants) (3/5 steps found)
- superpathway of L-threonine metabolism (12/18 steps found)
- L-cysteine biosynthesis VI (reverse transsulfuration) (4/7 steps found)
- glycine betaine degradation III (4/7 steps found)
- felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
- L-mimosine degradation (4/8 steps found)
- glycine betaine degradation I (4/8 steps found)
- purine nucleobases degradation II (anaerobic) (15/24 steps found)
- superpathway of L-methionine salvage and degradation (9/16 steps found)
- glutathione-mediated detoxification I (3/8 steps found)
- hypoglycin biosynthesis (4/14 steps found)
- superpathway of seleno-compound metabolism (6/19 steps found)
KEGG Metabolic Maps
- Cysteine metabolism
- Glycine, serine and threonine metabolism
- Methionine metabolism
- Nitrogen metabolism
- Selenoamino acid metabolism
- Sulfur metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.5.1.47, 4.4.1.1
Use Curated BLAST to search for 2.5.1.144 or 2.5.1.47 or 4.4.1.1 or 4.4.1.28
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9Z4V5 at UniProt or InterPro
Protein Sequence (290 amino acids)
>CA265_RS10150 cysteine synthase B (Pedobacter sp. GW460-11-11-14-LB5) MAGIIDLIGNTPMAELQKLNINPAVRVFAKLEGNNPGGSVKDRASLNMIRSAIERGDVVP GTKLVEATSGNTGIALAMIASLYNLEIELVMPANSTRERKVTMEAFGAKVTLLESIEDCR DYAEEKGVSKGYFLLNQFANPDNYLAHYKTTGPEIWRDTEGEITHFVSSMGTTGTIMGCS RFFKEKNNDIQIIGCQPTEGSSIPGIRRWPEEYLPKIFDPLRVDRVMDIAQEEATLMSRR MAKEEGLFAGMSSGGACAAALKLASELDKGTIVFIACDRGDRYLSSDLFG