Protein Info for CA265_RS06875 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: hydrophobe/amphiphile efflux-1 family RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1056 signal peptide" amino acids 9 to 11 (3 residues), see Phobius details transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 342 to 361 (20 residues), see Phobius details amino acids 368 to 388 (21 residues), see Phobius details amino acids 395 to 420 (26 residues), see Phobius details amino acids 441 to 462 (22 residues), see Phobius details amino acids 475 to 500 (26 residues), see Phobius details amino acids 543 to 561 (19 residues), see Phobius details amino acids 875 to 892 (18 residues), see Phobius details amino acids 899 to 921 (23 residues), see Phobius details amino acids 927 to 952 (26 residues), see Phobius details amino acids 973 to 993 (21 residues), see Phobius details amino acids 1007 to 1030 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1030 (1030 residues), 1010.8 bits, see alignment E=1e-307 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1034 (1032 residues), 1045.2 bits, see alignment E=0 PF03176: MMPL" amino acids 283 to 502 (220 residues), 30.7 bits, see alignment E=2.4e-11 PF02355: SecD_SecF" amino acids 325 to 485 (161 residues), 23.8 bits, see alignment E=4.1e-09

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 82% identity to phe:Phep_2952)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z2C6 at UniProt or InterPro

Protein Sequence (1056 amino acids)

>CA265_RS06875 hydrophobe/amphiphile efflux-1 family RND transporter (Pedobacter sp. GW460-11-11-14-LB5)
MFSKFIQRPVLSIVISLIIVFLGVLAISYLPVTQFPSISPPKVNITAEYPGANNELLIKS
VVIPLERALNGVPGMKYIASDAGNDGEASIQVVFNLGTDPNQASLNVQNRVAAVTNKLPP
LVVREGVKITREESNMLMYINLYSKDPKMNQNFLYNYADINLLSELKRVDGVGFADILGD
RDYAMRIWLKPDRMQAYKISVDEVMKALDEQSLEASPGKTGESSGKRSQAFEYVLKYSGR
FSTKEGYENVVLRASANGELLRLKDVADVDFSASAYNLYSTLNGKASAAIVLKQSYGSNA
SQVIKDVKAKMAEIKSSSFPKGLDYEVSYDVSKFLDASIEKVIHTLVEAFILVGLVVFLF
LGDWRSTLIPAIAVPVSLIGTFVFMQFFGITLNLITLFALVLAIGVVVDDAIVVIEAVHA
KMEHNRKLSVLKATQQAMKEIGGAIIAITFLMASVFIPVAFMSGPVGIFYRQFSITMATA
IILSGIVALTLTPALCAIMLKNNHGSKKKKTIIDRFLDGFNNGFAKLSGKYELVLTKVVS
RRILTFGILIAFCLGVWGLSGSVPSGFIPNEDQGMVYAIIQTPPGSTLERTDQISEKLQK
MCEDIDGVKSVSSLAGYEILTEGTGSNSGTCLINLKDWSERKHSAVEIIEELEEKSKSIP
GATIEFFQPPAVPGYGAAGGFELRLLDKAGSGDYKKMETVANDFVKELNKRKELSSVFTF
YSASFPQYMLDVDNDIAQQKGVSIDNAMNTLSTFVGSNYETSFIKYDHQYKVIVQALPQY
RALPEDILKLSVKNDRDEMVPFSAFIKMRKVYGLSEITRHNMYNASEISGQSAPGYSSGE
AIKAITEVAKKSLPRGFGIDWAGISKDEVSRGNEAIYIFLICLGFVYLVLAAQYESFILP
LSVILSLPAGIFGAFLFLKLLGLENNIYAQVAMVMLIGLLGKNAVLIVEFAAQRHAQGAS
VLKAAMEGASVRFRPILMTSFAFIAGLIPLMIASGPGKIGNRTIGSAAAGGMLFGTIFGV
VIIPGLYYVFGTIAARHKLIKIEEEHPLTEEVEDNV