Protein Info for CA265_RS06145 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: 9-O-acetylesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 661 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF03629: SASA" amino acids 109 to 238 (130 residues), 36.3 bits, see alignment E=4.8e-13 amino acids 422 to 540 (119 residues), 48.2 bits, see alignment E=1.1e-16 PF02837: Glyco_hydro_2_N" amino acids 275 to 379 (105 residues), 41.2 bits, see alignment E=1.8e-14

Best Hits

KEGG orthology group: K05970, sialate O-acetylesterase [EC: 3.1.1.53] (inferred from 54% identity to ppn:Palpr_2304)

Predicted SEED Role

"Sialic acid-specific 9-O-acetylesterase"

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.53

Use Curated BLAST to search for 3.1.1.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z2V5 at UniProt or InterPro

Protein Sequence (661 amino acids)

>CA265_RS06145 9-O-acetylesterase (Pedobacter sp. GW460-11-11-14-LB5)
MSIPRLKSILLIAFLLFSSQFIHAKILLPSVFSNNMVLQQKTNAAIWGKTDAGKAVKVTV
SWNKINYGAIADAGGNWKIKVATPGYGGPYTITISDGELLVLNNVLIGDVWICSGQSNME
MPLAGWGKILNSEKEIEAAQYPNIRLLQAEHVTSNFPLNDAKVANGGWQECSPKYIAEFS
STAYFFAREVYEKTKIPIGLIHTSWGGTIAEAWTSAESLKKMADFSAAVDKIQQSAKNPS
TISYEEKLYKWVKITNDKDSGNQDGQMKWALTESASWKNMTLPTLWEDAALKNFDGVVWF
TKKITIPENWKRDGAKLNLGTIDDNDITFINGVKVGETVGYNIERKYTIPANLLKVGENT
ITVRVFDSGGGGGLYDDTKDLNLTNGAADKISLAGEWKYKIGLDFKNIEPKPSEENGPNR
PTVLYNAMVHPYQQFSIKGAIWYQGESNADRAYQYRELFPTMIKDWRQKWAQGDFPFYFV
QLANFMQIDQTPVESAWAELREAQQKTLALPNTGMATIIDIGDAKDIHPKNKQEVGRRLA
LIALAKTYGQKINYAGPVYQSNKIEGKQILLTFGNSQNGLKTADGEALTGFAIAGADKKF
YWAKASILGNQIIVSSPQVANPVAVRYAWGNNPLCNLVSNDGLPASPFRTDTWQGITFAK
K