Protein Info for CA265_RS02050 in Pedobacter sp. GW460-11-11-14-LB5
Annotation: 4-hydroxy-tetrahydrodipicolinate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 55% identical to DAPA_FLAPJ: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 74% identity to phe:Phep_3319)MetaCyc: 40% identical to 4-hydroxy-tetrahydrodipicolinate synthase (Bacillus subtilis)
DIHYDRODIPICSYN-RXN [EC: 4.3.3.7]
Predicted SEED Role
"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)
MetaCyc Pathways
- aspartate superpathway (21/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- L-lysine biosynthesis II (8/9 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
- L-lysine biosynthesis III (6/7 steps found)
- L-lysine biosynthesis VI (6/7 steps found)
- L-lysine biosynthesis I (7/9 steps found)
- dipicolinate biosynthesis (3/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.52, 4.3.3.7
Use Curated BLAST to search for 4.2.1.52 or 4.3.3.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9YZY2 at UniProt or InterPro
Protein Sequence (295 amino acids)
>CA265_RS02050 4-hydroxy-tetrahydrodipicolinate synthase (Pedobacter sp. GW460-11-11-14-LB5) MNKFQGTGVALVTPFNTDGSVDYNGLKNLINHLVDGGIDYLVSLGTTGETATMTKDEKKK VWAYTAEINNNRLPLVAGIGGNNTLAVAEDIKSLDAAGYSAILSVSPYYNKPTQEGIYQH YKYLAEISPLDLILYNVPGRTGSNMSPETTCRLAHDFKNIIATKEASGSFDQFNQIMRDK PADFLLISGDDPVTLPMIALGAAGIISVIGNALPKQFSDMVKLCLAGDYKAALPAHLGLI EFTRLAFAEGNPAGIKAALKHLGVCGDTVRLPLVKASASLEKSIIAEIEKLSEVA